Evidence map›Paper›PMID 32605546›Full record

ArticleBMC ophthalmology2020

Elevated vitreous Lipocalin-2 levels of patients with proliferative diabetic retinopathy.

Hui Wang, Hui Lou, Yongrong Li, Fengtao Ji, Wei Chen, Qianyi Lu, Guoxu Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  14. Intraocular fluid biomarkers (liquid biopsy) in human diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hui WangDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China.
Hui LouDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China.
Yongrong LiDepartment of Ophthalmology, The Second People's Hospital of Hefei, Hefei, 230011, China.
Fengtao JiDepartment of Ophthalmology, The Second People's Hospital of Hefei, Hefei, 230011, China.
Wei ChenDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Qianyi LuDepartment of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Guoxu XuDepartment of Ophthalmology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, China. phacoxu@126.com.ORCID http://orcid.org/0000-0003-0173-3153
Soochow University · CNThird People's Hospital of Hefei · CNNantong University · CN

Funding

National Natural Science Foundation of China 81700847National Natural Science Foundation of China 81700855Natural Science Foundation of Jiangsu Province BK20170365
6 · The paper itself

Abstract

backgroundLipocalin-2 (LCN2) is a novel adipokine with potential roles in obesity, insulin resistance, and inflammation. This study aims to assess the concentrations of LCN2 and vascular endothelial growth factor (VEGF) expressed in the vitreous humors of patients with proliferative diabetic retinopathy (PDR).

methodsThe concentrations of LCN2 and VEGF were measured from the vitreous of 67 patients undergoing vitrectomy (20 controls and 47 PDR) via enzyme-linked immunosorbent assay (ELISA). Patients with non-ocular pathology that could elevate the LCN2 level in the vitreous were excluded. PDR activity and a history of panretinal photocoagulation were used for further grouping analysis.

resultsThe vitreous concentration of LCN2 was statistically significantly higher in the PDR group compared to the control group (63,522 (30,009) pg/ml versus 1663 (1191) pg/ml, respectively; P < 0.001). VEGF level was also significantly higher in the PDR group than in the control group (1038 (1326) pg/ml versus 9 pg/ml, respectively; P < 0.001). The mean vitreous LCN2 and VEGF levels in active PDR patients were significantly higher than that of the inactive PDR patients. The mean LCN2 concentration in vitreous humor was significantly lower in the 28 PDR patients with a history of complete PRP (37,304 (16,651) pg/mL) in comparison with 19 PDR patients without preperformed panretinal photocoagulation or with preperformed incomplete panretinal photocoagulation (79,796 (24,391) pg/mL). A significant correlation between the vitreous LCN2 level and VEGF level was found in patients with PDR (R = 0.34; P = 0.019).

conclusionsThis report shows a significant increase of LCN2 in the vitreous fluid of patients with PDR and present a significant correlation between LCN2 and VEGF, suggesting LCN2 might be involved in the pathogenesis of PDR.

Indexed as

Diabetes MellitusDiabetic RetinopathyLipocalin-2Enzyme-Linked Immunosorbent AssayHumansVascular Endothelial Growth Factor AVitrectomyVitreous BodyLCN2 protein, humanLipocalin-2Vascular Endothelial Growth Factor ADiabetic retinopathyLipocalin-2Vascular endothelial growth factor

Identifiers

PMID32605546
PMCPMC7329527
OpenAlexW3040009463

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.