ArticleBMC genomics2020
Influence of genetic diversity of seventeen Beauveria bassiana isolates from different hosts on virulence by comparative genomics.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 59 citations in OpenAlex.
- Gene presence-absence and evolutionary signals of positive selection associated with virulence divergence inMicrobial genomics · 2026Article
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- Intra-Phenotypic and -Genotypic Variations ofInternational journal of molecular sciences · 2024Article
- Safety of the Entomopathogenic FungusInsects · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Computational identification and characterization of chitinase 1 and chitinase 2 from neotropical isolates ofFrontiers in bioinformatics · 2024Article
- Hypovirulence-associated mycovirus epidemics cause pathogenicity degeneration of Beauveria bassiana in the field.Virology journal · 2023Article
- First record ofFrontiers in microbiology · 2023Article
- A Sensitive Method for DetectingThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Draft Genome Sequences of Eight Isolates of Beauveria bassiana of Neotropical Origin.Microbiology resource announcements · 2022Article
- Virulence ofInsects · 2021Article
- Distribution and Diversity ofMicroorganisms · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundBeauveria bassiana (B. bassiana) is a famous entomopathogenic fungus that could parasitize on hundreds of insect species, which are being used as an environmentally friendly mycoinsecticide. Nevertheless, the possible effect of genetic diversity of these B. bassiana isolates from different hosts on virulence has not been explored before. In order to explore that issue, we compared the genome sequences among seventeen B. bassiana isolates from 17 different insects using whole genome re-sequencing, with B. bassiana strain ARSEF 2860 as the reference genome.
resultsThere were a total of 10,098 missense mutated genes, 720 positively selected genes were identified in 17 strains of B. bassiana. Among these, two genes with high frequency mutations encode the toxin-producing non-ribosomal peptide synthase (NRPS) protein. Seven genes undergoing positive selection were enriched in the two-component signaling pathway that is known to regulate the fungal toxicity. In addition, the domain changes of three positively selected genes are also directly related to the virulence plasticity. Besides, the functional categorization of mutated genes showed that most of them involved in the biological functions of toxic proteins involved in.
conclusionsBased on our data, our results indicate that several mutated genes and positively selected genes may underpin virulence of B. bassiana towards hosts during infection process, which provide an insight into the potential effects of natural variation on the virulence of B. bassiana, which will be useful in screening out potential virulence factors in B. bassiana.
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