Evidence map›Paper›PMID 32605384›Full record

SynthesisCirculation. Genomic and precision medicine2020

Meta-Analysis of 26 638 Individuals Identifies Two Genetic Loci Associated With Left Ventricular Ejection Fraction.

Hélène Choquet, Khanh K Thai, Chen Jiang, Dilrini K Ranatunga, Thomas J Hoffmann, Alan S Go, Alistair C Lindsay, Margaret G Ehm, Dawn M Waterworth, Neil Risch and 1 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Circulating Cardiovascular Proteomic Associations With Genetics and Disease.Circulation. Genomic and precision medicine · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  11. The genetics of human performance.Nature reviews. Genetics · 2022
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hélène ChoquetDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Khanh K ThaiDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Chen JiangDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Dilrini K RanatungaDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Thomas J HoffmannInstitute for Human Genetics (T.J.H., N.R.), UCSF, San Francisco, CA.
Alan S GoDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Alistair C LindsayGlaxoSmithKline, Collegeville, PA (A.C.L., M.G.E., D.M.W.).
Margaret G EhmGlaxoSmithKline, Collegeville, PA (A.C.L., M.G.E., D.M.W.).
Dawn M WaterworthGlaxoSmithKline, Collegeville, PA (A.C.L., M.G.E., D.M.W.).
Neil RischDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Catherine SchaeferDivision of Research, Kaiser Permanente Northern California (KPNC), Oakland, CA (H.C., K.K.T., C.J., D.K.R., A.S.G., N.R., C.S.).
Kaiser Permanente · USGlaxoSmithKline (United States) · USCancer Research And Biostatistics · US

Funding

A Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIA NIH HHS RC2 AG036607
6 · The paper itself

Abstract

backgroundLeft ventricular ejection fraction (EF) is an indicator of cardiac function, usually assessed in individuals with heart failure and other cardiac conditions. Although family studies indicate that EF has an important genetic component with heritability estimates up to 0.61, to date only 6 EF-associated loci have been reported.

methodsHere, we conducted a genome-wide association study (GWAS) of EF in 26 638 adults from the Genetic Epidemiology Research on Adult Health and Aging and the UK Biobank cohorts.

resultsA meta-analysis combining results from Genetic Epidemiology Research on Adult Health and Aging and UK Biobank identified a novel locus:

conclusionsIn this large and multiethnic study, we identified 2 loci,

Indexed as

Genome-Wide Association StudyAdaptor Proteins, Signal TransducingAgedApoptosis Regulatory ProteinsAsian PeopleBlack PeopleFemaleGene FrequencyGenetic LociGenetic VariationHeart FailureHumansMaleMembrane ProteinsMiddle AgedQuantitative Trait, HeritableAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBAG3 protein, humanMembrane ProteinsTMEM40 protein, humanchromosomesgeneticsgenome-wide association studyheart failurehumans

Identifiers

PMID32605384
PMCPMC7446727
OpenAlexW3039260968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.