Evidence map›Paper›PMID 32605171›Full record

ArticleInternational journal of molecular sciences2020

Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-

Hyerim Song, Yun Jeong Hwang, Jae Won Ha, Yong Chool Boo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Hirsutanone Isolated from the Bark ofPlants (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hyerim SongDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Yun Jeong HwangDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Jae Won HaDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Yong Chool BooDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Korea.
Kyungpook National University · KR

Funding

National Research Foundation of Korea No. 2019R1I1A2A01045132
6 · The paper itself

Abstract

The aim of this study was to identify novel antimelanogenic drugs from an epigenetic screening library containing various modulators targeting DNA methyltransferases, histone deacetylases, and other related enzymes/proteins. Of 141 drugs tested, K8 (4-((hydroxyamino)carbonyl)-

Indexed as

Epigenesis, GeneticAnimalsAntineoplastic AgentsBenzeneacetamidesMelaninsMelanoma, ExperimentalMiceMicrophthalmia-Associated Transcription FactorMonophenol MonooxygenasePharmaceutical PreparationsTumor Cells, CulturedAntineoplastic AgentsBenzeneacetamidesMelaninsMicrophthalmia-Associated Transcription FactorMitf protein, mouseMonophenol MonooxygenasePharmaceutical Preparations4-((hydroxyamino)carbonyl)-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamideantimelanogenic drugepigenetic screening libraryHPOBmelaninpigmentationtyrosinasetyrosinase inhibitor

Identifiers

PMID32605171
PMCPMC7370187
OpenAlexW3037002398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.