Evidence map›Paper›PMID 32605043›Full record

ArticleMolecules (Basel, Switzerland)2020

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes.

Zeynep Mirza, Ernesto R Soto, Yan Hu, Thanh-Thanh Nguyen, David Koch, Raffi V Aroian, Gary R Ostroff

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Microorganisms · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Molecules (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zeynep MirzaProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Ernesto R SotoProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-9540-8476
Yan HuProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Thanh-Thanh NguyenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
David KochProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Gary R OstroffProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
University of Massachusetts Chan Medical School · US

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
Automated high throughput compound screening for broadly active anti-parasitic nematode drugsR01AI150866 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2020 to 2024
$2.5M
Foundation for the National Institutes of Health R01AI056189 and R01AI50866NIAID NIH HHS R01 AI056189NIAID NIH HHS R01 AI150866USDA National Institute of Food and Agriculture 2015-11323
6 · The paper itself

Abstract

Soil-transmitted nematodes (STN) infect 1-2 billion of the poorest people worldwide. Only benzimidazoles are currently used in mass drug administration, with many instances of reduced activity. Terpenes are a class of compounds with anthelmintic activity. Thymol, a natural monoterpene phenol, was used to help eradicate hookworms in the U.S. South circa 1910. However, the use of terpenes as anthelmintics was discontinued because of adverse side effects associated with high doses and premature stomach absorption. Furthermore, the dose-response activity of specific terpenes against STNs has been understudied. Here we used hollow, porous yeast particles (YPs) to efficiently encapsulate (>95%) high levels of terpenes (52%

Indexed as

AlbendazoleAncylostomaAncylostomatoideaAnimalsAnthelminticsBenzimidazolesHumansNematodaNematode InfectionsSaccharomyces cerevisiaeTerpenesAlbendazoleAnthelminticsBenzimidazolesTerpenesanthelminticessential oilshookwormterpeneswhipwormyeast particles

Identifiers

PMID32605043
PMCPMC7411854
OpenAlexW3037581488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.