ArticleGenes2020
Gene Networks Driving Genetic Variation in Milk and Cheese-Making Traits of Spanish Assaf Sheep.
Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.Veterinary and animal science · 2026Review
- Candidate gene search for milk production and composition, milk coagulation properties, and milk protein profile in dairy sheep from a New Zealand flock.Animal biotechnology · 2025Article
- A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits.BMC genomics · 2025Article
- Investigation of selection signatures of dairy goats using whole-genome sequencing data.BMC genomics · 2025Article
- Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach.Epigenetics · 2024Article
- Exploring Breed-Specific Milk Coagulation in Spanish Dairy Sheep: A Canonical Correlation Approach.Animals : an open access journal from MDPI · 2024Article
- Article
- Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat.Frontiers in genetics · 2022Article
- A comprehensive genome-wide scan detects genomic regions related to local adaptation and climate resilience in Mediterranean domestic sheep.Genetics, selection, evolution : GSE · 2021Article
- Detection of genomic regions underlying milk production traits in Valle del Belice dairy sheep using regional heritability mapping.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of the milk produced by sheep is used for the production of high-quality cheese. Consequently, traits related to milk coagulation properties and cheese yield are economically important to the Spanish dairy industry. The present study aims to identify candidate genes and their regulators related to 14 milk and cheese-making traits and to develop a low-density panel of markers that could be used to predict an individual's genetic potential for cheese-making efficiency. In this study, we performed a combination of the classical genome-wide association study (GWAS) with a stepwise regression method and a pleiotropy analysis to determine the best combination of the variants located within the confidence intervals of the potential candidate genes that may explain the greatest genetic variance for milk and cheese-making traits. Two gene networks related to milk and cheese-making traits were created using the genomic relationship matrices built through a stepwise multiple regression approach. Several co-associated genes in these networks are involved in biological processes previously found to be associated with milk synthesis and cheese-making efficiency. The methodology applied in this study enabled the selection of a co-association network comprised of 374 variants located in the surrounding of genes showing a potential influence on milk synthesis and cheese-making efficiency.
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Registered trials
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