Evidence map›Paper›PMID 32604880›Full record

ArticleMarine drugs2020

Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation.

Francisca García, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farías, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima and 4 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  6. Astaxanthin Alleviates Autoimmune Hepatitis by Modulating CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Francisca GarcíaLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Pedro LobosBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-0831-1079
Alejandra PonceLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Karla CataldoLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Daniela MezaLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Patricio FaríasLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Carolina EstayLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
Felipe Oyarzun-AmpueroDepartment of Technology and Pharmaceutical Sciences, Faculty of Chemical and Pharmaceutical Sciences, Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380494, Chile.
Rodrigo Herrera-MolinaLeibniz Institute for Neurobiology, 39118 Magdeburg, Germany.ORCID 0000-0001-9597-5131
Andrea Paula-LimaBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.
Álvaro O ArdilesLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.ORCID 0000-0001-8295-2133
Cecilia HidalgoBiomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380000, Chile.
Tatiana AdasmeCentro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, Santiago 8370854, Chile.ORCID 0000-0002-0840-1912
Pablo MuñozLaboratory of Cellular and Molecular Plasticity, Department of Pathology and Physiology, Medical School, Faculty of Medicine, Universidad de Valparaíso, Valparaíso 2341386, Chile.
University of Valparaíso · CLUniversity of Chile · CLUniversidad Bernardo O'Higgins · CLAdvanced Center for Chronic Diseases · CL

Funding

Corporación de Fomento de la Producción 13IDL2-18271Fondo Nacional de Desarrollo Científico y Tecnológico 11140580Fondo Nacional de Desarrollo Científico y Tecnológico 1150736Fondo Nacional de Desarrollo Científico y Tecnológico 1170053
6 · The paper itself

Abstract

Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca

Indexed as

AnimalsCalciumCells, CulturedHippocampusHumansMitochondriaNeuroblastomaNeuronsNeuroprotective AgentsN-MethylaspartatePrimary Cell CultureRatsReactive Oxygen SpeciesXanthophyllsastaxanthineCalciumNeuroprotective AgentsN-MethylaspartateReactive Oxygen SpeciesXanthophyllsastaxanthincalciumexcitotoxicitymitochondrial superoxideNMDA

Identifiers

PMID32604880
PMCPMC7345213
OpenAlexW3037029052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.