ReviewNanomaterials (Basel, Switzerland)2020
Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review.
Review in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nanoscale Morphologies on the Surface of 3D-Printed Titanium Implants for Improved Osseointegration: A Systematic Review of the Literature.International journal of nanomedicine · 2023Pooled it
- Near-Infrared-Induced Hydrophobic Characteristic of Black TiOJournal of functional biomaterials · 2026Article
- Insight into Surface Properties of Anodic Oxidized Ti6Al7Nb Alloy for Biomedical Applications.Materials (Basel, Switzerland) · 2026Article
- Nano-engineering the titanium-tissue interface: a 15 year perspective on bio-functionalization and surface innovation.Nanoscale advances · 2026Review
- Biomechanical evaluation of implant materials and connection designs: a structured narrative review of titanium and zirconia.Odontology · 2026Review
- Biomimetic Deposition of Zn-Doped Calcium Phosphate Coatings on Surface-Activated Ti6Al4V for Multifunctional Implant Interfaces.Journal of functional biomaterials · 2026Article
- Influence of rhBMP-2 and rhBMP-7 in fibrin on osseointegration of SLA implants: a preclinical evaluation.Scientific reports · 2026Article
- Probing the Phase Composition and Surface Roughness in the Biological Response of Additively Manufactured Titanium Alloy Bioimplants.ACS omega · 2026Article
- Bonding of Hydrogel to Biometal Surfaces: Principles, Methods and Applications.Exploration (Beijing, China) · 2025Review
- Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium.International journal of molecular sciences · 2025Article
- Citrus-Fruit-Based Hydroxyapatite Anodization Coatings on Titanium Implants.Materials (Basel, Switzerland) · 2025Article
- Anti-Bacterial Properties and Hemocompatibility of Alkali Treated Nano-Structured Micro-Porous Titanium Surfaces.Biomimetics (Basel, Switzerland) · 2025Article
- Comparison Between Micro- and Micro-Nano Surface Texturization in the Initial Osseointegration Process: An Experimental In Vitro and In Vivo Preclinical Study.Bioengineering (Basel, Switzerland) · 2025Article
- Long-Term Clinical Study on Sandblasted-Acid-Etched Surface Dental Implants: 12-Year Follow-Up.Materials (Basel, Switzerland) · 2025Article
- The Influence of Implant Surface Modification on Marginal Bone Loss and Periodontal Health: A Cross-Over Randomized Clinical Trial.International journal of dentistry · 2025Article
- Review
- Osseointegration Process ImprovingCurrent topics in medicinal chemistry · 2025Review
- 3D-ink-extruded titanium scaffolds with porous struts and bioactive supramolecular polymers for orthopedic implants.Acta biomaterialia · 2024Article
- Advanced porous hip implants: A comprehensive review.Heliyon · 2024Review
- Innovative PEEK in Dentistry of Enhanced Adhesion and Sustainability through AI-Driven Surface Treatments.Bioengineering (Basel, Switzerland) · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The propose of this review was to summarize the advances in multi-scale surface technology of titanium implants to accelerate the osseointegration process. The several multi-scaled methods used for improving wettability, roughness, and bioactivity of implant surfaces are reviewed. In addition, macro-scale methods (e.g., 3D printing (3DP) and laser surface texturing (LST)), micro-scale (e.g., grit-blasting, acid-etching, and Sand-blasted, Large-grit, and Acid-etching (SLA)) and nano-scale methods (e.g., plasma-spraying and anodization) are also discussed, and these surfaces are known to have favorable properties in clinical applications. Functionalized coatings with organic and non-organic loadings suggest good prospects for the future of modern biotechnology. Nevertheless, because of high cost and low clinical validation, these partial coatings have not been commercially available so far. A large number of in vitro and in vivo investigations are necessary in order to obtain in-depth exploration about the efficiency of functional implant surfaces. The prospective titanium implants should possess the optimum chemistry, bionic characteristics, and standardized modern topographies to achieve rapid osseointegration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.