ArticleLife (Basel, Switzerland)2020
Rat Animal Model of Pectus Excavatum.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Influence of chest wall conformation on spirometry parameters and outcome in mild-to-moderate idiopathic pulmonary fibrosis.Internal and emergency medicine · 2022Article
- Current Concepts in the Etiology and Pathogenesis of Pectus Excavatum in Humans-A Systematic Review.Journal of clinical medicine · 2022Review
- Costal cartilage overgrowth does not induce pectus-like deformation in the chest wall of a rat model.Experimental and therapeutic medicine · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundpectus excavatum (PE) is the most common congenital deformity of the thoracic wall. Lately, significant achievements have been made in finding new, less invasive treatment methods for PE. However, most of the experimental work was carried out without the help of an animal model. In this report we describe a method to create an animal model for PE in Sprague-Dawley rats.
methodsWe selected 15 Sprague-Dawley rat pups and divided them into two groups: 10 for the experimental group (EG) and 5 for the control group (CG). We surgically resected the last four pairs of costal cartilages in rats from the EG. The animals were assessed by CT-scan prior to surgery and weekly for four consecutive weeks. After four weeks, the animals were euthanized and the thoracic cage was dissected from the surrounding tissue.
resultsOn the first postoperative CT, seven days after surgery, we observed a marked depression of the lower sternum in all animals from the EG. This deformity was present at every CT-scan after surgery and at the post-euthanasia assessment.
conclusionsBy decreasing the structural strength of the lower costal cartilages, we produced a PE animal model in Sprague-Dawley rats.
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