Evidence map›Paper›PMID 32604411›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.

Mark W Tenforde, Thandi Milton, Ikanyeng Rulaganyang, Charles Muthoga, Leabaneng Tawe, Tom Chiller, Gregory Greene, Alexander Jordan, Christopher G Williams, Leah Owen and 5 more

Open access · greenAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Tracking Cryptococcal Meningitis to Monitor HIV Program Success During the Treat All Era: An Analysis of National Data in Botswana.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Mark W TenfordeDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Thandi MiltonBotswana-UPenn Partnership, Gaborone, Botswana.
Ikanyeng RulaganyangBotswana-UPenn Partnership, Gaborone, Botswana.
Charles MuthogaBotswana-UPenn Partnership, Gaborone, Botswana.
Leabaneng TaweBotswana-UPenn Partnership, Gaborone, Botswana.
Tom ChillerMycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Gregory GreeneMycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Alexander JordanMycotics Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Christopher G WilliamsBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Leah OwenBotswana-UPenn Partnership, Gaborone, Botswana.
Tshepo B LeemeBotswana-UPenn Partnership, Gaborone, Botswana.
Amber BooseBotswana-UPenn Partnership, Gaborone, Botswana.
Julia NgidiBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Madisa MineBotswana National Health Laboratory, Gaborone, Botswana.
Joseph N JarvisBotswana-UPenn Partnership, Gaborone, Botswana.
Botswana Open University · BWBotswana Harvard AIDS Institute Partnership · BWCenters for Disease Control and Prevention · USUniversity of Washington · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
Cryptococcal antigen screening for the prevention of cryptococcal meningitis in the HIV "treat-and-treat" era: A prospective cohort and semi-quantitative lateral flow assay validation studyF32AI140511 · NIAID · UNIVERSITY OF WASHINGTON · PI TENFORDE, MARK · 2018 to 2018
$65k
NIAID NIH HHS F32 AI140511NIAID NIH HHS P30 AI045008NIAID NIH HHS T32 AI007044
6 · The paper itself

Abstract

Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.

Indexed as

AIDS-Related Opportunistic InfectionsCryptococcusHIV InfectionsMeningitis, CryptococcalAntigens, FungalBotswanaCD4 Lymphocyte CountHIVHumansMass ScreeningReflexAntigens, Fungaladvanced HIVantiretroviral therapycryptococcal antigenHIV/AIDSHIV treat all

Identifiers

PMID32604411
PMCPMC8096249
OpenAlexW3040556771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.