ReviewCurrent opinion in genetics & development2020
Adaptive viscoelasticity of epithelial cell junctions: from models to methods.
Review in Current opinion in genetics & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA.The journal of gene medicine · 2025Review
- Temporal Contrastive Learning through implicit non-equilibrium memory.Nature communications · 2025Article
- Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns.Biophysical journal · 2025Article
- Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading.Soft matter · 2022Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- Article
- Characterization of the strain-rate-dependent mechanical response of single cell-cell junctions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Epithelial morphogenesis relies on constituent cells' ability to finely tune their mechanical properties. Resulting elastic-like and viscous-like behaviors arise from mechanochemical signaling coordinated spatiotemporally at cell-cell interfaces. Direct measurement of junction rheology can mechanistically dissect mechanical deformations and their molecular origins. However, the physical basis of junction viscoelasticity has only recently become experimentally tractable. Pioneering studies have uncovered exciting findings on the nature of contractile forces and junction deformations, inspiring a fundamentally new way of understanding morphogenesis. Here, we discuss novel techniques that directly test junctional mechanics and describe the relevant Vertex Models, and adaptations thereof, capturing these data. We then present the concept of adaptive tissue viscoelasticity, revealed by optogenetic junction manipulation. Finally, we offer future perspectives on this rapidly evolving field describing the material basis of tissue morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.