ArticleNeurobiology of aging2020
Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories.
Abstract read
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Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis.Frontiers in medicine · 2026Article
- APOE genotype influences on the brain metabolome of aging mice - role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype.Molecular neurodegeneration · 2025Article
- Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions.Nature communications · 2025Article
- The APOE-Microglia Axis in Alzheimer's Disease: Functional Divergence and Therapeutic Perspectives-A Narrative Review.Brain sciences · 2025Review
- Variable and interactive effects of Sex, APOEResearch square · 2024Article
- Can Genetic Markers Predict the Sporadic Form of Alzheimer's Disease? An Updated Review on Genetic Peripheral Markers.International journal of molecular sciences · 2023Review
- APOE effects on regional tau in preclinical Alzheimer's disease.Molecular neurodegeneration · 2023Article
- Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.BMC neurology · 2022Article
- Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain.Neurobiology of aging · 2022Article
- Predictive Scale for Amyloid PET Positivity Based on Clinical and MRI Variables in Patients with Amnestic Mild Cognitive Impairment.Journal of clinical medicine · 2022Article
- Article
- Imaging beta-amyloid (Aβ) burden in the brains of middle-aged individuals with alcohol-use disorders: a [Translational psychiatry · 2021Article
- Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging.Alzheimer's research & therapy · 2021Article
- Risk of dementia inAlzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- White matter microstructure disruption in early stage amyloid pathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- APOE and amyloid-tau pathology in cognitively unimpaired older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
14 authors.
Brian J LoprestiDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: BrianL@pitt.edu.
Elizabeth M CampbellDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zheming YuDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Stewart J AndersonDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Ann D CohenDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Davneet S MinhasDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Beth E SnitzDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sarah K RoyseDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Carl R BeckerDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Chester A MathisDepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Oscar L LopezDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William E KlunkDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dana L TudorascuDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Funding
Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5MTREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0MResearch Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4MPredictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities FrameworkR01AG072641 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ann D. Cohen · 2022 to 2026
$9.6MRoles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyRF1AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, VILLEMAGNE, VICTOR LUIS · 2014 to 2021
$9.0MRoles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyR01AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Victor Luis Villemagne · 2024 to 2026
$4.4MAMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLYR37AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLUNK, WILLIAM E · 2005 to 2014
$4.3MNIA NIH HHS P01 AG025204NIA NIH HHS P30 AG066468NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG025516NIA NIH HHS R01 AG072641NIA NIH HHS R37 AG025516NIA NIH HHS RF1 AG025516
Abstract
To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and longitudinal Aβ trajectories, [
Indexed as
GenotypeAgedAged, 80 and overAge of OnsetAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E2Apolipoproteins EBrainCohort StudiesFemaleHumansMaleMiddle AgedPositron-Emission TomographyRiskAmyloid beta-PeptidesApolipoprotein E2Apolipoproteins EAlzheimer's diseaseAmyloidApolipoprotein-EGeneticsPositron emission tomography (PET)
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.