Evidence map›Paper›PMID 32603605›Full record

ArticleCirculation. Genomic and precision medicine2020

Jason R Cowan, Lorien Salyer, Nathan T Wright, Daniel D Kinnamon, Pedro Amaya, Elizabeth Jordan, Michael J Bamshad, Deborah A Nickerson, Ray E Hershberger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Cytokine Storm-Definition, Causes, and Implications.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jason R CowanDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.
Lorien SalyerDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA (N.T.W.).
Daniel D KinnamonDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.
Pedro AmayaDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.
Elizabeth JordanDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.
Michael J BamshadDepartment of Pediatrics (M.J.B.), University of Washington, Seattle.
Deborah A NickersonDepartment of Genome Sciences (D.A.N.), University of Washington, Seattle.
Ray E HershbergerDorothy M. Davis Heart and Lung Research Institute (J.R.C., L.S., D.D.K., P.A., E.J., R.E.H.), Department of Internal Medicine, The Ohio State University College of Medicine, Columbus.

Funding

YOUTH, Osteoporosis, and Understanding Total Health (YOUTH)M01RR000334 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DORSA, DANIEL MICHAEL · 1985 to 2006
$30.6M
UW Center for Mendelian GenomicsUM1HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, LEAL, SUZANNE M · 2016 to 2020
$15.3M
Precision Medicine for Dilated Cardiomyopathy in European and African AncestryR01HL128857 · NHLBI · OHIO STATE UNIVERSITY · PI HERSHBERGER, RAY E. · 2015 to 2020
$12.4M
FAMILIAL DILATED CARDIOMYOPATHY--DETECTION/GENE MAPPINGR01HL058626 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HERSHBERGER, RAY E. · 1998 to 2011
$6.0M
NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
NCRR NIH HHS M01 RR000334NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006493NHLBI NIH HHS R01 HL058626NHLBI NIH HHS R01 HL128857
6 · The paper itself

Abstract

backgroundDilated cardiomyopathy (DCM) is a genetically heterogeneous cardiac disease characterized by progressive ventricular enlargement and reduced systolic function. Here, we report genetic and functional analyses implicating the rat sarcoma signaling protein, SOS1 (Son of sevenless homolog 1), in DCM pathogenesis.

methodsExome sequencing was performed on 412 probands and family members from our DCM cohort, identifying several

resultsA rare

conclusionsThese data support gain-of-function variation in

Indexed as

AdolescentAdultAgedCardiomyopathy, DilatedExome SequencingExtracellular Signal-Regulated MAP KinasesFamilyGain of Function MutationHumansMiddle AgedPedigreePhosphorylationPolymorphism, GeneticProtein Structure, TertiaryRisk FactorsSeverity of Illness IndexExtracellular Signal-Regulated MAP KinasesSOS1 Proteincardiomyopathy, dilatedgeneticsrisk factorsson of sevenless proteinsSOS1 protein

Identifiers

PMID32603605
PMCPMC7462086

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.