ArticleAmerican journal of respiratory and critical care medicine2020
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Current strategies and opportunities to manufacture cells for modeling human lungs.Advanced drug delivery reviews · 2020Pooled it
- Single-cell RNA sequencing reveals aberrant airway epithelial-immune cell cross-talk in pulmonary fibrosis.ERJ open research · 2026Article
- Alveolar macrophage subtypes express cholesterol and inflammation genes in cystic fibrosis.Life science alliance · 2026Article
- Intrinsic neutrophil dysregulation in programmed cell death promotes neutrophilic inflammation in cystic fibrosis.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- The single-cell transcriptional landscape of the pediatric cystic fibrosis lung from minimally invasive respiratory specimens.Scientific reports · 2026Article
- Recruited Monocyte-Derived Macrophages Drive T Cell Inflammation in Immune Checkpoint Inhibitor-Mediated Pneumonitis.Cancer communications (London, England) · 2026Article
- Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.Theranostics · 2026Review
- Differential roles of resident lung macrophages during control of murine alveolar and airwayFrontiers in tuberculosis · 2026Article
- Single-cell transcriptomics of granulocytes in asthma and atopic diseases.Frontiers in molecular biosciences · 2026Review
- Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis.bioRxiv : the preprint server for biology · 2025Article
- Single-cell RNA-sequencing co-expression analysis with CFTR and CF modifier genes in lung tissue.Scientific reports · 2025Article
- Transcriptomic and functional responses of the cystic fibrosis airway epithelium to CFTR modulator therapy.JCI insight · 2025Article
- Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025Article
- Article
- Revealing the impact ofFrontiers in immunology · 2025Article
- Ezrin drives adaptation of monocytes to the inflamed lung microenvironment.Cell death & disease · 2024Article
- Allergic Bronchopulmonary Aspergillosis (ABPA) in the Era of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators.Journal of fungi (Basel, Switzerland) · 2024Review
- Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine.American journal of respiratory and critical care medicine · 2024Review
- Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation.Nature medicine · 2024Article
- Pharmacological Improvement of Cystic Fibrosis Transmembrane Conductance Regulator Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis.American journal of respiratory and critical care medicine · 2024Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Jonas C SchuppSection of Pulmonary, Critical Care, and Sleep Medicine.ORCID 0000-0002-7714-8076
Sara KhanalSection of Pulmonary, Critical Care, and Sleep Medicine.ORCID 0000-0002-0295-3900
Jose L GomezSection of Pulmonary, Critical Care, and Sleep Medicine.
Maor SaulerSection of Pulmonary, Critical Care, and Sleep Medicine.
Taylor S AdamsSection of Pulmonary, Critical Care, and Sleep Medicine.
Geoffrey L ChuppSection of Pulmonary, Critical Care, and Sleep Medicine.
Xiting YanSection of Pulmonary, Critical Care, and Sleep Medicine.
Sergio PoliBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Yujiao ZhaoDepartment of Internal Medicine, and.
Ruth R MontgomeryDepartment of Internal Medicine, and.
Ivan O RosasBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.
Charles S Dela CruzSection of Pulmonary, Critical Care, and Sleep Medicine.
Emanuela M BrusciaDivision of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Marie E EganDivision of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Naftali KaminskiSection of Pulmonary, Critical Care, and Sleep Medicine.
Clemente J BrittoSection of Pulmonary, Critical Care, and Sleep Medicine.
SleepMed · USBrigham and Women's Hospital · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTraining Translational Lung Biology and PathobiologyT32HL007778 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog, NAFTALI KAMINSKI · 1994 to 2026
$14.4MGenomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9MSystems Biology of a MicroRNA Network in Neutrophilic AsthmaR01HL153604 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2020 to 2024
$3.4MRole of MIF and CD74 in the pathogenesis of emphysemaR01HL155948 · NHLBI · YALE UNIVERSITY · PI BUCALA, RICHARD J, SAULER, MAOR · 2021 to 2025
$3.4MNormal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8MSPLUNC1 and Neutrophilic Inflammation in Cystic FibrosisK01HL125514 · NHLBI · YALE UNIVERSITY · PI BRITTO-LEON, CLEMENTE · 2015 to 2021
$905kMIF and DNA repair in the emphysematous lungK08HL135402 · NHLBI · YALE UNIVERSITY · PI SAULER, MAOR · 2017 to 2021
$842kFunctional role of hsa-miR-504 in airway inflammation and remodeling in asthmaK01HL125474 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2015 to 2019
$835kDeep and Integrative Analysis of RNA Sequencing Data to Identify Pathogenesis Heterogeneity of Chronic Lung DiseaseR21LM012884 · NLM · YALE UNIVERSITY · PI YAN, XITING · 2018 to 2019
$415kSputum-Based Profiling to Predict Cystic Fibrosis ExacerbationsR03HL154276 · NHLBI · YALE UNIVERSITY · PI BRITTO-LEON, CLEMENTE · 2020 to 2021
$168kRegulation of Neutrophilic Airway Inflammation by miR-223-3pR03HL154275 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2020 to 2021
$168kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS K01 HL125474NHLBI NIH HHS K01 HL125514NHLBI NIH HHS K08 HL135402NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL153604NHLBI NIH HHS R01 HL155948NHLBI NIH HHS R03 HL154275NHLBI NIH HHS R03 HL154276NHLBI NIH HHS T32 HL007778NHLBI NIH HHS U01 HL145567NLM NIH HHS R21 LM012884
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overAirway ResistanceCystic FibrosisFemaleHumansInflammationMaleMiddle AgedSingle-Cell AnalysisTranscriptional Activationcystic fibrosismacrophagesmonocytesneutrophilsRNA-seq
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.