ArticleActa physiologica (Oxford, England)2021
Intact vagal gut-brain signalling prevents hyperphagia and excessive weight gain in response to high-fat high-sugar diet.
Article in Acta physiologica (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 43 citations in OpenAlex.
- Gut-brain communication: Functional anatomy of vagal afferents.Current opinion in neurobiology · 2025Review
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Naringenin Decreases Retroperitoneal Adiposity and Improves Metabolic Parameters in a Rat Model of Western Diet-Induced Obesity.Metabolites · 2025Article
- GLP-1 and the Neurobiology of Eating Control: Recent Advances.Endocrinology · 2025Review
- Ascending Vagal Sensory and Central Noradrenergic Pathways Modulate Retrieval of Passive Avoidance Memory in Male Rats.Journal of neuroscience research · 2024Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- An ascending vagal sensory-central noradrenergic pathway modulates retrieval of passive avoidance memory.bioRxiv : the preprint server for biology · 2024Article
- Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.Cell metabolism · 2024Article
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- Article
- Gut microbiota suppress feeding induced by palatable foods.Current biology : CB · 2023Article
- Neural Pathway for Gut Feelings: Vagal Interoceptive Feedback From the Gastrointestinal Tract Is a Critical Modulator of Anxiety-like Behavior.Biological psychiatry · 2022Article
- Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors.Appetite · 2022Article
- Nutrient-Based Appetite Regulation.Journal of obesity & metabolic syndrome · 2022Review
- Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-Induced Weight Gain in Male Mice.Nutrients · 2021Article
- Gut-brain communication and obesity: understanding functions of the vagus nerve.The Journal of clinical investigation · 2021Review
- Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety.Scientific reports · 2021Article
- Fat and Carbohydrate Interact to Potentiate Food Reward in Healthy Weight but Not in Overweight or Obesity.Nutrients · 2021Observational
- Intact vagal gut-brain signalling prevents hyperphagia and excessive weight gain in response to high-fat high-sugar diet.Acta physiologica (Oxford, England) · 2021Article
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6 authors at 4 institutions in 1 country.
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Abstract
aimThe tools that have been used to assess the function of the vagus nerve lack specificity. This could explain discrepancies about the role of vagal gut-brain signalling in long-term control of energy balance. Here we use a validated approach to selectively ablate sensory vagal neurones that innervate the gut to determine the role of vagal gut-brain signalling in the control of food intake, energy expenditure and glucose homoeostasis in response to different diets.
methodsRat nodose ganglia were injected bilaterally with either the neurotoxin saporin conjugated to the gastrointestinal hormone cholecystokinin (CCK), or unconjugated saporin as a control. Food intake, body weight, glucose tolerance and energy expenditure were measured in both groups in response to chow or high-fat high-sugar (HFHS) diet. Willingness to work for fat or sugar was assessed by progressive ratio for orally administered solutions, while post-ingestive feedback was tested by measuring food intake after an isocaloric lipid or sucrose pre-load.
resultsVagal deafferentation of the gut increases meal number in lean chow-fed rats. Switching to a HFHS diet exacerbates overeating and body weight gain. The breakpoint for sugar or fat solution did not differ between groups, suggesting that increased palatability may not drive HFHS-induced hyperphagia. Instead, decreased satiation in response to intra-gastric infusion of fat, but not sugar, promotes hyperphagia in CCK-Saporin-treated rats fed with HFHS diet.
conclusionsWe conclude that intact sensory vagal neurones prevent hyperphagia and exacerbation of weight gain in response to a HFHS diet by promoting lipid-mediated satiation.
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