ArticleBJOG : an international journal of obstetrics and gynaecology2021
Magnetic resonance imaging measurement of placental perfusion and oxygen saturation in early-onset fetal growth restriction.
Article in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 49 citations in OpenAlex.
- Digital instrument simulator platform to support the development of noninvasive optical NIR device for placenta monitoring.Journal of biomedical optics · 2026Article
- The human placenta and its role in reproductive outcomes revisited.Physiological reviews · 2025Review
- The hypoxic fetus as a patient: adaptations to the intrauterine environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Exploration of normal placental blood flow characteristics in middle and late pregnancy based on microvascular flow imaging.Pakistan journal of medical sciences · 2025Article
- Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction.International journal of molecular sciences · 2025Article
- Placental quantitative susceptibility mapping and T2* characteristics for predicting birth weight in healthy and high-risk pregnancies.European radiology experimental · 2025Article
- Long-Term Neurologic Consequences following Fetal Growth Restriction: The Impact on Brain Reserve.Developmental neuroscience · 2025Review
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model†.Biology of reproduction · 2024Article
- Maternal tadalafil treatment does not increase uterine artery blood flow or oxygen delivery in the pregnant ewe.Experimental physiology · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Scientific reports · 2024Article
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Research square · 2024Article
- Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease.Frontiers in cardiovascular medicine · 2024Review
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: moving from controversy to consensus definitions and subclassification.Pediatric research · 2023Article
- Non-invasive mapping of human placenta microenvironments throughout pregnancy with diffusion-relaxation MRI.Placenta · 2023Article
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Low-Field Combined Diffusion-Relaxation MRI for Mapping Placenta Structure and Function.medRxiv : the preprint server for health sciences · 2023Article
- Differences in placental oxygenation and perfusion status between fetal growth-restricted and small-for-gestational-age pregnancies: a functional magnetic resonance imaging study.European radiology · 2023Article
- Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes.Magnetic resonance in medicine · 2023Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveWe hypothesised that a multi-compartment magnetic resonance imaging (MRI) technique that is sensitive to fetal blood oxygenation would identify changes in placental blood volume and fetal blood oxygenation in pregnancies complicated by early-onset fetal growth restriction (FGR).
designCase-control study.
settingLondon, UK. POPULATION: Women with uncomplicated pregnancies (estimated fetal weight [EFW] >10th centile for gestational age [GA] and normal maternal and fetal Doppler ultrasound, n = 12) or early-onset FGR (EFW <3rd centile with or without abnormal Doppler ultrasound <32 weeks GA, n = 12) were studied.
methodsAll women underwent MRI examination. Using a multi-compartment MRI technique, we quantified fetal and maternal blood volume and feto-placental blood oxygenation.
main outcome measuresDisease severity was stratified according to Doppler pulsatility index and the relationship to the MRI parameters was investigated, including the influence of GA at scan.
resultsThe FGR group (mean GA 27
conclusionUsing a novel multimodal MRI protocol we demonstrated reduced feto-placental blood oxygen saturation in pregnancies complicated by early-onset FGR. The degree of abnormality correlated with disease severity defined by ultrasound Doppler findings. Gestational age-dependent changes in oxygen saturation were also present in normal pregnancies. TWEETABLE ABSTRACT: MRI reveals differences in feto-placental oxygen saturation between normal and FGR pregnancy that is associated with disease severity.
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