Evidence map›Paper›PMID 32603486›Full record

ReviewFundamental & clinical pharmacology2020

Potential drug-drug interactions associated with drugs currently proposed for COVID-19 treatment in patients receiving other treatments.

Florian Lemaitre, Caroline Solas, Matthieu Grégoire, Laurence Lagarce, Laure Elens, Elisabeth Polard, Béatrice Saint-Salvi, Agnès Sommet, Michel Tod, Chantal Barin-Le Guellec and 1 more

Abstract readReview
In one paragraph

Review in Fundamental & clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Polypharmacy among COVID-19 patients: A systematic review.Journal of the American Pharmacists Association : JAPhA
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions.European journal of drug metabolism and pharmacokinetics · 2023
    Review
  7. Review
  8. Article
  9. Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Review
  10. Review
  11. Impact of theInfection and drug resistance · 2022
    Article
  12. Drug Interactions for Patients with Respiratory Diseases Receiving COVID-19 Emerged Treatments.International journal of environmental research and public health · 2021
    Review
  13. Scoping insight on antiviral drugs against COVID-19.Arabian journal of chemistry · 2021
    Review
  14. ANMCO POSITION PAPER: cardio-oncology in the COVID era (CO and CO).European heart journal supplements : journal of the European Society of Cardiology · 2021
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Florian LemaitreUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, F-35000, France.ORCID https://orcid.org/0000-0002-0908-3629
Caroline SolasAix-Marseille University, APHM, UMR "Emergence des Pathologies Virales" Inserm 1207 IRD 190, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille, 13005, France.
Matthieu GrégoireClinical Pharmacology Department, CHU Nantes, Nantes Cedex 1, Nantes, 44093, France.ORCID https://orcid.org/0000-0003-1232-5761
Laurence LagarceService de Pharmacologie-Toxicologie et Pharmacovigilance, Centre Hospitalo-Universitaire d'Angers, Angers, 49100, France.
Laure ElensIntegrated Pharmacometrics, Pharmacogenomics and Pharmacokinetics (PMGK), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCL), Louvain, Belgique.
Elisabeth PolardUniv Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, F-35000, France.
Béatrice Saint-SalviMedical Interactions Unit, Agence National de Sécurité du Médicaments et des produits de santé, Saint-Denis, 93200, France.
Agnès SommetDepartment of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, INSERM UMR 1027, CIC 1426, Toulouse University Hospital, Faculty of Medicine, University of Toulouse, Toulouse, 31000, France.
Michel TodPharmacy, Croix-Rousse Hospital, Lyon, 69005, France.
Chantal Barin-Le GuellecLaboratoire de Biochimie et de Biologie Moléculaire, CHU de Tours, Tours, F37044, France.
French Society of Pharmacology, Therapeutics (SFPT), the International Association of Therapeutic Drug Monitoring, Clinical Toxicology (IATDMCT)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with COVID-19 are sometimes already being treated for one or more other chronic conditions, especially if they are elderly. Introducing a treatment against COVID-19, either on an outpatient basis or during hospitalization for more severe cases, raises the question of potential drug-drug interactions. Here, we analyzed the potential or proven risk of the co-administration of drugs used for the most common chronic diseases and those currently offered as treatment or undergoing therapeutic trials for COVID-19. Practical recommendations are offered, where possible.

Indexed as

AnalgesicsAnti-Asthmatic AgentsAnti-Bacterial AgentsAnticoagulantsAnti-Inflammatory AgentsAntineoplastic AgentsAntitubercular AgentsAntiviral AgentsBetacoronavirusCardiovascular AgentsCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug InteractionsHumansHydroxychloroquineAnalgesicsAnti-Asthmatic AgentsAnti-Bacterial AgentsAnticoagulantsAnti-Inflammatory AgentsAntineoplastic AgentsAntitubercular AgentsAntiviral AgentsCardiovascular AgentsHydroxychloroquineHypoglycemic AgentsHypolipidemic AgentsInterferon beta-1bPrescription DrugsPsychotropic DrugsReceptors, InterleukinThyroid Hormonesadverse eventshydroxychloroquinelopinavirpharmacodynamicspharmacokineticstherapeutic drug monitoring

Identifiers

PMID32603486
PMCPMC7361515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.