Evidence map›Paper›PMID 32603465›Full record

ArticleTexas Heart Institute journal2020

Zinc Deficiency as a Reversible Cause of Heart Failure.

Hannah Rosenblum, Behnood Bikdeli, Jeffrey Wessler, Aakriti Gupta, Daniel Louis Jacoby

Abstract readCase Reports
In one paragraph

Article in Texas Heart Institute journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Interplay between ZnInternational journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hannah RosenblumDepartment of Medicine, Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York 10032.
Behnood BikdeliDepartment of Medicine, Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York 10032.
Jeffrey WesslerDepartment of Medicine, Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York 10032.
Aakriti GuptaDepartment of Medicine, Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York 10032.
Daniel Louis JacobySection of Cardiovascular Medicine, Department of Internal Medicine, Yale New Haven Hospital, New Haven, Connecticut 06510.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Zinc, an essential micronutrient, affects the heart by modulating cardiomyocyte oxidative stress and maintaining myocardial structure, among other mechanisms. In cross-sectional studies, patients with heart failure have often had zinc deficiencies, suggesting effects on the ongoing pathogenesis of heart failure. Low plasma and myocardial zinc levels may cause reversible cardiomyopathy in patients who have nutritional deficiencies. We present the case of a 24-year-old woman with anorexia nervosa and new-onset heart failure whose depressed left ventricular systolic function improved after zinc supplementation. To our knowledge, this is the first report of low plasma zinc levels as the chief cause of cardiomyopathy that resolved after zinc supplementation.

Indexed as

Anorexia NervosaBiomarkersEchocardiographyFemaleHeart FailureHeart VentriclesHumansMalnutritionYoung AdultZincBiomarkersZincCardiomyopathies/blooddisease progressionfemaleheart failure/blood/diet therapy/etiology/physiopathologymicronutrients/therapeutic usenutritional physiological phenomenatreatment outcomeventricular dysfunction, leftzinc/blood/deficiency/therapeutic use

Identifiers

PMID32603465
PMCPMC7328074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.