ArticlePloS one2020
Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- The Reallocation of Sedentary Time Is Associated with Longitudinal Improvements in Cardiometabolic Outcomes during Childhood.The Journal of pediatrics · 2025Article
- Association of triglyceride-glucose-related indices with adverse clinical outcomes in individuals with normal body mass index.Frontiers in cardiovascular medicine · 2025Article
- Longitudinal associations between vitamin D status and biomarkers of inflammation in a pan-European cohort of children and adolescents.European journal of nutrition · 2024Article
- Assessment of Sleep Quality in Adolescents with Overweight and Obesity Using the Adolescent Sleep Hygiene Scale (ASHS).Children (Basel, Switzerland) · 2024Article
- A longitudinal causal graph analysis investigating modifiable risk factors and obesity in a European cohort of children and adolescents.Scientific reports · 2024Article
- Sleep duration and insulin resistance in obese adolescents with metabolic syndrome: is there a correlation?Acta bio-medica : Atenei Parmensis · 2023Observational
- Sleep duration and timing are prospectively linked with insulin resistance during late adolescence.Obesity (Silver Spring, Md.) · 2023Article
- Associations between socioeconomic status and risk of obesity and overweight among Chinese children and adolescents.BMC public health · 2023Article
- Adherence to 24-h movement guidelines in Spanish schoolchildren and its association with insulin resistance: a cross-sectional study.Frontiers in public health · 2023Article
- Association of Healthy Eating Index-2015 and Dietary Approaches to Stop Hypertension Patterns with Insulin Resistance in Schoolchildren.Nutrients · 2022Article
- Associations Between Sleep and Metabolic Outcomes in Preadolescent Children.Journal of the Endocrine Society · 2022Article
- Article
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes.Current diabetes reports · 2021Review
- Physical Activity, Screen-Based Sedentary Behavior and Physical Fitness in Chinese Adolescents: A Cross-Sectional Study.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundShort sleep duration has been suggested to lead to insulin resistance both directly by altering glucose metabolism and indirectly through obesity. This study aims to investigate associations between nocturnal sleep duration and insulin resistance considering abdominal obesity as a mediator.
methodsWe analysed data of 3 900 children aged 2-15 years participating in the second (2009/10) and third (2013/14) examination wave of the European IDEFICS/I.Family study (hereafter referred to as baseline and follow-up). Information on nocturnal sleep duration was collected by questionnaires and age-standardised (SLEEP z-score). The homeostasis model assessment (HOMA) was calculated from fasting insulin and fasting glucose obtained from blood samples; waist circumference (WAIST) was measured with an inelastic tape. HOMA and WAIST were used as indicators for insulin resistance and abdominal obesity, respectively, and transformed to age- and sex-specific z-scores. Cross-sectional and longitudinal associations between SLEEP z-score and HOMA z-score were investigated based on a path model considering WAIST z-score as a mediator adjusting for relevant confounders.
resultsCross-sectionally, baseline SLEEP z-score was negatively associated with baseline WAIST z-score (unstandardised effect estimate -0.120, 95% confidence interval [-0.167; -0.073]). We observed no direct effect of baseline SLEEP z-score on baseline HOMA z-score but a negative indirect effect through baseline WAIST z-score (-0.042 [-0.058; -0.025]). Longitudinally, there was no direct effect of baseline SLEEP z-score on HOMA z-score at follow-up but a negative indirect effect through both baseline WAIST z-score and WAIST z-score at follow-up (-0.028 [-0.040; -0.016]).
conclusionsOur results do not support the hypothesis of an association between short sleep duration and insulin resistance independent of abdominal obesity. However, longer sleep duration may exert short and long term beneficial effects on insulin resistance through its beneficial effects on abdominal obesity.
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