ArticleAmerican journal of respiratory cell and molecular biology2020
Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice.
Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Leptin alleviates obesity hypoventilationbioRxiv : the preprint server for biology · 2026Article
- Melanocortin receptor 4 agonist setmelanotide treats opioid-induced respiratory depression.bioRxiv : the preprint server for biology · 2026Article
- Targeted Delivery of CNS-Specific Hesperidin as a Leptin Sensitizer for Treating Obesity-Associated Sleep-Disordered Breathing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Detection of central and obstructive sleep apneas in mice: A new surgical and recording protocol.PloS one · 2025Article
- Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity.Cell reports · 2023Article
- The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.Frontiers in physiology · 2023Article
- Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Leptin-loaded Extracellular Vesicles Treat Sleep-disordered Breathing in Mice with Obesity.American journal of respiratory cell and molecular biology · 2022Article
- Opioid Use Disorder, Sleep Deficiency, and Ventilatory Control: Bidirectional Mechanisms and Therapeutic Targets.American journal of respiratory and critical care medicine · 2022Article
- Review
- Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.Clinics in chest medicine · 2022Review
- Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.Respiratory research · 2022Article
- The effect of brain serotonin deficiency on breathing is magnified by age.Physiological reports · 2022Article
- Buprenorphine differentially alters breathing among four congenic mouse lines as a function of dose, sex, and leptin status.Respiratory physiology & neurobiology · 2022Article
- Opioids and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Review
- Obstructive sleep apnea.Handbook of clinical neurology · 2022Review
- Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity?American journal of respiratory cell and molecular biology · 2021Article
- Article
- Intranasal leptin improves survival after opioid overdose in a mouse model.Journal of translational medicine · 2021Article
- Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity.Frontiers in physiology · 2021Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Respiratory depression is the main cause of morbidity and mortality associated with opioids. Obesity increases opioid-related mortality, which is mostly related to comorbid obstructive sleep apnea. Naloxone, a μ-opioid receptor blocker, is an effective antidote, but it reverses analgesia. Like humans with obesity, mice with diet-induced obesity hypoventilate during sleep and develop obstructive sleep apnea, which can be treated with intranasal leptin. We hypothesized that intranasal leptin reverses opioid-induced sleep-disordered breathing in obese mice without decreasing analgesia. To test this hypothesis, mice with diet-induced obesity were treated with morphine at 10 mg/kg subcutaneously and with leptin or placebo intranasally. Sleep and breathing were recorded by barometric plethysmography, and pain sensitivity was measured by the tail-flick test. Excitatory postsynaptic currents were recorded
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.