Evidence map›Paper›PMID 32603262›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2020

Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis.

Íngrid Martí-Pàmies, Robrecht Thoonen, Patrick Seale, Alexia Vite, Alex Caplan, Jesus Tamez, Lauren Graves, Wei Han, Emmanuel S Buys, Donald B Bloch and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. GDF10 promotes rodent cardiomyocyte maturation during the postnatal period.Journal of molecular and cellular cardiology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Transgenic Expression ofInternational journal of molecular sciences · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Íngrid Martí-PàmiesCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Robrecht ThoonenCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts.
Patrick SealeInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Alexia ViteCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Alex CaplanCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Jesus TamezCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Lauren GravesCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Wei HanCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Emmanuel S BuysAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Donald B BlochAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Marielle Scherrer-CrosbieCardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · USCardiovascular Institute of the South · USMassachusetts General Hospital · USHarvard University · US

Funding

Brown Adipose Tissue and CardioprotectionR01HL131613 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHERRER-CROSBIE, MARIELLE · 2017 to 2020
$1.6M
HHS | National Institutes of Health (NIH) R01-HL-131613NHLBI NIH HHS R01 HL131613
6 · The paper itself

Abstract

Bone morphogenetic protein (BMP) receptor signaling is critical for the regulation of the endocrine system and cardiovascular structure and function. The objective of this study was to investigate whether Bmp3b, a glycoprotein synthetized and secreted by adipose tissue, is necessary to regulate glucose and lipid metabolism, adipogenesis, and cardiovascular remodeling. Over the course of 4 mo,

Indexed as

AdipocytesAdipogenesisAdipose TissueAnimalsBone Morphogenetic Protein 3DyslipidemiasFemaleGlucose IntoleranceGrowth Differentiation Factor 10Heart DiseasesInsulin ResistanceMaleMetabolic SyndromeMiceMice, Inbred C57BLMice, KnockoutBmp3 protein, mouseBone Morphogenetic Protein 3Growth Differentiation Factor 10adipokinesadipose tissuecardiac remodelingdiabetesmetabolic syndrome

Identifiers

PMID32603262
PMCPMC7473912
OpenAlexW3038520800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.