Evidence map›Paper›PMID 32602838›Full record

ArticleeLife2020

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation.

Ljuvica R Kolich, Ya-Ting Chang, Nicolas Coudray, Sabrina I Giacometti, Mark R MacRae, Georgia L Isom, Evelyn M Teran, Gira Bhabha, Damian C Ekiert

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Suppressors ofInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. ABC Transporters in Bacterial Nanomachineries.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Lipid Transport Across Bacterial Membranes.Annual review of cell and developmental biology · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ljuvica R Kolich *Department of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0002-6696-9645
Ya-Ting Chang *Department of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0003-2580-4622
Nicolas Coudray *Department of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0002-6050-2219
Sabrina I GiacomettiDepartment of Cell Biology, New York University School of Medicine, New York, United States.
Mark R MacRaeDepartment of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0003-4941-9526
Georgia L IsomDepartment of Cell Biology, New York University School of Medicine, New York, United States.
Evelyn M TeranDepartment of Cell Biology, New York University School of Medicine, New York, United States.
Gira BhabhaDepartment of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0003-0624-6178
Damian C EkiertDepartment of Cell Biology, New York University School of Medicine, New York, United States.ORCID 0000-0002-2570-0404
New York University · US

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Unravelling lipid trafficking for the bacterial outer membraneR35GM128777 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Damian Ekiert · 2018 to 2026
$4.1M
Eliminating Critical Systematic Errors In Structural Biology With Next-Generation SimulationR01GM124149 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLTON, JAMES M · 2017 to 2024
$2.5M
Training program in Molecular BiophysicsT32GM088118 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STOKES, DAVID L. · 2010 to 2019
$1.8M
Structure and mechanism of cytoplasmic and axonemal dyneinsR00GM112982 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHABHA, GIRA · 2017 to 2019
$747k
Damon Runyon Cancer Research Foundation DFS-20-16NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R00 GM112982NIGMS NIH HHS R01 GM124149NIGMS NIH HHS R35 GM128777NIGMS NIH HHS T32 GM088118NIH HHS T32 GM088118
6 · The paper itself

Abstract

ABC transporters facilitate the movement of diverse molecules across cellular membranes, but how their activity is regulated post-translationally is not well understood. Here we report the crystal structure of MlaFB from

Indexed as

ATP-Binding Cassette TransportersEscherichia coliEscherichia coli ProteinsMolecular StructureATP-Binding Cassette TransportersEscherichia coli ProteinsMlaF protein, E coliABC transportersbacterial outer membraneE. coliMlaBMlaFmolecular biophysicsSTAS domainstructural biologyx-ray crystallography

Identifiers

PMID32602838
PMCPMC7367683
OpenAlexW3039414441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.