ArticleRadiology2020
Three-dimensional US for Quantification of Volumetric Blood Flow: Multisite Multisystem Results from within the Quantitative Imaging Biomarkers Alliance.
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Article in Radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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8 citing papers in PubMed.
- Forward-Viewing Intravascular Ultrasound: Design and Fabrication for High Sensitivity 3D Imaging of Hemodynamics.IEEE transactions on bio-medical engineering · 2026Article
- Intravascular ultrasound wall shear stress imaging in stented coronary arteries with ultrafast Doppler.Scientific reports · 2026Article
- Following the flow: in vivo imaging of fetal foramen ovale physiology using four-dimensional flow magnetic resonance imaging with doppler ultrasound gating.Radiology case reports · 2026Article
- Color Flow Ultrasound Spatial Sampling Beam Density for Partial Volume-Corrected Three-Dimensional Volume Flow (3DVF): Theory, Simulation, and Experiment.Ultrasound in medicine & biology · 2024Article
- Umbilical Vein Pulse Wave Spectral Analysis: A Possible Method for Placental Assessment Through Evaluation of Maternal and Fetal Flow Components.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2022Article
- Volumetric Flow Assessment in Doppler Ultrasonography in Risk Stratification of Patients with Internal Carotid Stenosis and Occlusion.Journal of clinical medicine · 2022Article
- Comparison of Variations Between Spectral Doppler and Gaussian Surface Integration Methods for Umbilical Vein Blood Volume Flow.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Article
- Three-dimensional US Measurements of Blood Flow: One Step Closer to Clinical Practice.Radiology · 2020Article
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Authors and funding
15 authors.
Oliver D KripfgansFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-2905-1496
Stephen Z PinterFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).
Cristel BaiuFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0002-9763-2957
Matthew F BruceFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).
Paul L CarsonFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-3543-7424
Shigao ChenFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-3460-127X
Todd N ErpeldingFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-4899-561X
Jing GaoFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0001-5993-042X
Mark E LockhartFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0002-0669-7449
Andy MilkowskiFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0002-4349-2899
Nancy ObuchowskiFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-1891-7477
Michelle L RobbinFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0003-4456-5081
Jonathan M RubinFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0002-6643-486X
James A ZagzebskiFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).
J Brian FowlkesFrom the Department of Radiology, Michigan Medicine, University of Michigan, 1301 Catherine St, Med Sci I R3218D, Ann Arbor, MI 48109-5667 (O.D.K., S.Z.P., P.L.C., J.M.R., J.B.F.); Sun Nuclear, Middleton, Wis (C.B.); University of Washington, Seattle, Wash (M.F.B.) Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minn (S.C.); Canon Medical Systems USA, Tustin, Calif (T.N.E.); Department of Ultrasound in Research and Education, Rocky Vista University, Ivins, Utah (J.G.); Department of Diagnostic Radiology, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (N.O.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R., M.E.L.); Siemens Healthcare, Issaquah, Wash (A.M.); and Department of Medical Physics, University of Wisconsin-Madison, Madison, Wis (J.A.Z.).ORCID 0000-0002-4536-3919
Funding
3D Umbilical Venous Blood Flow - A New Paradigm for Improving the Assessment of Fetal Growth Restriction.R01HD097756 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI FOWLKES, JEFFREY B, LEE, WESLEY · 2019 to 2023
$3.2MAssessment of Placental Blood Volume Flow and Function in IUGR Using a Transfer Function ModelR21HD095501 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBIN, JONATHAN M · 2019 to 2020
$448kNHLBI NIH HHS HHSN268201500021CNIBIB NIH HHS HHSN268201000050CNIBIB NIH HHS HHSN268201300071CNICHD NIH HHS R01 HD097756NICHD NIH HHS R21 HD095501
Abstract
Background Quantitative blood flow (QBF) measurements that use pulsed-wave US rely on difficult-to-meet conditions. Imaging biomarkers need to be quantitative and user and machine independent. Surrogate markers (eg, resistive index) fail to quantify actual volumetric flow. Standardization is possible, but relies on collaboration between users, manufacturers, and the U.S. Food and Drug Administration. Purpose To evaluate a Quantitative Imaging Biomarkers Alliance-supported, user- and machine-independent US method for quantitatively measuring QBF. Materials and Methods In this prospective study (March 2017 to March 2019), three different clinical US scanners were used to benchmark QBF in a calibrated flow phantom at three different laboratories each. Testing conditions involved changes in flow rate (1-12 mL/sec), imaging depth (2.5-7 cm), color flow gain (0%-100%), and flow past a stenosis. Each condition was performed under constant and pulsatile flow at 60 beats per minute, thus yielding eight distinct testing conditions. QBF was computed from three-dimensional color flow velocity, power, and scan geometry by using Gauss theorem. Statistical analysis was performed between systems and between laboratories. Systems and laboratories were anonymized when reporting results. Results For systems 1, 2, and 3, flow rate for constant and pulsatile flow was measured, respectively, with biases of 3.5% and 24.9%, 3.0% and 2.1%, and -22.1% and -10.9%. Coefficients of variation were 6.9% and 7.7%, 3.3% and 8.2%, and 9.6% and 17.3%, respectively. For changes in imaging depth, biases were 3.7% and 27.2%, -2.0% and -0.9%, and -22.8% and -5.9%, respectively. Respective coefficients of variation were 10.0% and 9.2%, 4.6% and 6.9%, and 10.1% and 11.6%. For changes in color flow gain, biases after filling the lumen with color pixels were 6.3% and 18.5%, 8.5% and 9.0%, and 16.6% and 6.2%, respectively. Respective coefficients of variation were 10.8% and 4.3%, 7.3% and 6.7%, and 6.7% and 5.3%. Poststenotic flow biases were 1.8% and 31.2%, 5.7% and -3.1%, and -18.3% and -18.2%, respectively. Conclusion Interlaboratory bias and variation of US-derived quantitative blood flow indicated its potential to become a clinical biomarker for the blood supply to end organs. © RSNA, 2020
Indexed as
BiomarkersBlood Flow VelocityBlood VesselsConstriction, PathologicImaging, Three-DimensionalModels, CardiovascularPhantoms, ImagingProspective StudiesUltrasonography, Doppler, ColorBiomarkers
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