Evidence map›Paper›PMID 32602777›Full record

ArticleRNA biology2020

Splice variants of lncRNA RNA ANRIL exert opposing effects on endothelial cell activities associated with coronary artery disease.

Hyosuk Cho, Yabo Li, Stephen Archacki, Fan Wang, Gang Yu, Susmita Chakrabarti, Yang Guo, Qiuyun Chen, Qing Kenneth Wang

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Review
  13. Role of LncRNAs in the Pathogenesis of Coronary Artery Disease.Reviews in cardiovascular medicine · 2023
    Review
  14. Article
  15. The Roles ofGenes · 2022
    Review
  16. Long Noncoding RNAMolecular and cellular biology · 2022
    Article
  17. Article
  18. Frontiers in cell and developmental biology · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Hyosuk ChoDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine , Cleveland, OH, USA.ORCID 0000-0003-0592-9102
Yabo LiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.ORCID 0000-0002-8954-7007
Stephen ArchackiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.
Fan WangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.ORCID 0000-0001-9806-5037
Gang YuDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.ORCID 0000-0002-8496-8814
Susmita ChakrabartiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.ORCID 0000-0003-1197-2780
Yang GuoDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.ORCID 0000-0001-7430-7038
Qiuyun ChenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic , Cleveland, OH, USA.
Qing Kenneth WangDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine , Cleveland, OH, USA.ORCID 0000-0002-5639-8519
Cleveland Clinic Lerner College of Medicine · US

Funding

NGS in Large CAD Families: In-Depth Identification of Rare Risk Genomic VariantsR01HL121358 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, QING KENNETH · 2014 to 2017
$2.8M
Targeting Nav1.5 trafficking as a therapy for lethal genetic cardiac arrhythmiasR01HL126729 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WANG, QING KENNETH · 2015 to 2018
$1.6M
Targeting a novel AGGF1 signaling pathway for therapy of pulmonary hypertensionR01HL138465 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEN, QIUYUN, WANG, QING KENNETH · 2019 to 2019
$559k
NHLBI NIH HHS R01 HL121358NHLBI NIH HHS R01 HL126729NHLBI NIH HHS R01 HL138465
6 · The paper itself

Abstract

Each gene typically has multiple alternatively spliced transcripts. Different transcripts are assumed to play a similar biological role; however, some transcripts may simply lose their function due to loss of important functional domains. Here, we show that two different transcripts of lncRNA gene

Indexed as

Alternative SplicingGene Expression RegulationBiomarkersCell AdhesionCoronary Artery DiseaseCoronary VesselsDisease SusceptibilityEndothelial CellsGene Knockdown TechniquesHumansMonocytesRNA IsoformsRNA, Long NoncodingTransendothelial and Transepithelial MigrationBiomarkersCDKN2B antisense RNA, humanRNA IsoformsRNA, Long NoncodingANRIL (CDKN2B-AS1)coronary artery disease (CAD) and myocardial infarction (MI)EZRlncRNAmonocyte adhesion to endothelial cellsTMEM106Btransendothelial migration of monocytes

Identifiers

PMID32602777
PMCPMC7549722
OpenAlexW3040639196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.