Evidence map›Paper›PMID 32602696›Full record

ArticleACS nano2020

Bulk Self-Assembly of Giant, Unilamellar Vesicles.

James T Kindt, Jack W Szostak, Anna Wang

Abstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Devising a divisome for synthetic cells.Nature reviews. Chemistry · 2026
    Review
  3. Article
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  8. Article
  9. Review
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  11. Article
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  13. Article
  14. Passive endocytosis in model protocells.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Passive endocytosis in model protocells.bioRxiv : the preprint server for biology · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James T KindtDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-9050-8144
Jack W SzostakDepartment of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID 0000-0003-4131-1203
Anna WangDepartment of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.ORCID 0000-0002-2148-1996

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

The desire to create cell-like models for fundamental science and applications has spurred extensive effort toward creating giant unilamellar vesicles (GUVs). However, a route to selectively self-assemble GUVs in bulk has remained elusive. In bulk solution, membrane-forming molecules such as phospholipids, single-tailed surfactants, and block copolymers typically self-assemble into multilamellar, onion-like structures. So although self-assembly processes can form nanoscale unilamellar vesicles, scaffolding by droplets or surfaces is required to create GUVs. Here we show that it is possible to bulk self-assemble cell-sized GUVs with almost complete selectivity over other vesicle topologies. The seemingly paradoxical pair of features that enables this appears to be having very

Indexed as

PhospholipidsUnilamellar LiposomesPolymersSurface-Active AgentsPhospholipidsPolymersSurface-Active AgentsUnilamellar Liposomesgiant unilamellar vesicleliposomemembraneorigins of lifeprotocellself-assemblyvesicle

Identifiers

PMID32602696
PMCPMC8172239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.