ReviewESC heart failure2020
Anaemia, iron deficiency and heart failure in 2020: facts and numbers.
Review in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05122793 ("HerzCheck" - Erkennung Und Prävention Einer Frühen Herzinsuffizienz Mittels Telemedizinischer Verfahren in Strukturschwachen Regionen), which is not on this map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"HerzCheck" - Erkennung Und Prävention Einer Frühen Herzinsuffizienz Mittels Telemedizinischer Verfahren in Strukturschwachen Regionen
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Impact of anemia on clinical outcomes in patients with acute heart failure: A systematic review and meta-analysis.Clinical cardiology · 2024Pooled it
- Trial
- Longitudinal Changes in Hematological Status and Functional Capacity During Hospitalization Are Associated With Clinical Outcomes in Older Patients With Acute Decompensated Heart Failure.Circulation reports · 2026Article
- Dynamic patterns of anemia and cognitive function: a longitudinal cohort study based on the China Health and Retirement Longitudinal Study.BMC public health · 2026Article
- Iron Deficiency Screening in Patients Admitted with Acute Heart Failure Decompensation.Journal of cardiovascular translational research · 2026Article
- Association of Intravenous Versus Oral Iron Therapy With Clinical Outcomes in Patients With Advanced CKD.Kidney medicine · 2026Article
- Recent change in bridging strategy and improved clinical outcomes following durable left ventricular assist device implantation in Japan.JHLT open · 2026Article
- Prevalence of anemia in adult heart failure patients at Saint Paul's hospital millennium medical college and Saint Peter's speialized hospital in Addis Ababa Ethiopia: a cross sectional study.BMC cardiovascular disorders · 2026Article
- Association of polycythemia with outcomes of acute decompensated heart failure: A matched and weighted cohort analysis.PloS one · 2026Article
- Impact of iron deficiency on health-related quality of life and functional status in adults with chronic heart failure in Nigeria.BMC cardiovascular disorders · 2025Article
- Unmasking anemia in the elderly: A systematic review of prevalence, causes, and consequences.Journal of family medicine and primary care · 2025Review
- Impact of non-cardiovascular factors on cardiovascular death in acute decompensated heart failure: Enhancing predictive models with frailty and comorbid constipation-the Constipation and Frailty Augmented AHEAD score.Geriatrics & gerontology international · 2025Article
- Review
- Epidemiology and treatment of patients with iron deficiency and iron deficiency anemia: a study on longitudinal German health claims data.BMC public health · 2025Article
- Predictive machine-learning model for screening iron deficiency without anaemia: a retrospective cohort study.BMJ open · 2025Article
- Prediction of three-year all-cause mortality in patients with heart failure and atrial fibrillation using the CatBoost model.BMC cardiovascular disorders · 2025Article
- Epigenetic modifications of nuclear and mitochondrial DNA are associated with the disturbance of serum iron biomarkers among the metabolically unhealthy obesity school-age children.Nutrition journal · 2025Article
- Analysis of prevalence, years lived with disability, and trends of anemia burden and main causes in China.Frontiers in public health · 2025Article
- Article
- The Intersection of Heart Failure and Iron Deficiency Anemia: Diagnostic and Therapeutic Approaches.Current cardiology reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaemia is defined by WHO as Hb < 13.0 g/dL in male adults and <12.0 g/dL in female adults. It is a common comorbidity in patients of heart failure with both HFrEF and HFpEF. The incidence ranges between 30% and 50%, though in certain communities, it is likely to be higher still. Elderly age, severe heart failure, poor nutrition, and elevation of inflammatory markers are associated with a higher incidence of anaemia. However, the commonest contributing factor to anaemia in HF is iron deficiency. In a Canadian study of 12 065 patients, the incidence of absolute ID was 21% in anaemic patients. Many other western studies have also quoted incidences varying between 35% and 43%. The earlier attempts to improve outcomes by supplementation with Erythropoietic-stimulating factors were unsuccessful and resulted in a higher incidence of thrombotic events. Iron deficiency (ID) has emerged as an important factor in patients of HF, even in those without anaemia and worsens outcomes. It is defined as Ferritin levels below 100 mcg/L or 100-299 μg/L with transferrin saturation of <20%. Attempts to correct ID by oral supplementation have been unsuccessful as seen in IRON-HF and IRONOUT-HF trials. FAIR-HF and CONFIRM-HF conclusively established the role of IV Iron in improving exercise capacity and quality of life in patients with HFrEF. ESC guidelines have given a class IC indication for testing all heart failure patients for ID, and an IIaA recommendation for its correction by IV ferric carboxymaltose was found to be deficient. Ongoing trials will establish the role of IV iron in improving mortality and in HFpEF patients and in patients with acute heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.