ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2021
Embryologically Based Classification Specifies Gender Differences in the Prevalence of Orofacial Cleft Subphenotypes.
Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Tooth Auto-Transplantation in Patients with Cleft Lip and/or Palate: A Systematic Review and Preliminary Clinical Protocol Proposal.Journal of clinical medicine · 2026Review
- A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts.Pediatric discovery · 2026Review
- Comprehensive analysis ofmedRxiv : the preprint server for health sciences · 2026Article
- Evaluation of hard palate and cleft morphology in neonates with Pierre Robin Sequence and Cleft Palate Only.Orthodontics & craniofacial research · 2024Article
- Orofacial Cleft and Its Association with Consanguineous Marriage and Other Risk Factors: A Case-control Study from a Tertiary Care Hospital in Jammu Province.International journal of clinical pediatric dentistry · 2024Article
- Self-perceived oral health and orofacial aesthetics of cleft patients.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Analysis of Consanguinity as Risk Factor of Nonsyndromic Cleft Lips with or without Palate.European journal of dentistry · 2024Article
- The Global Occurrences of Cleft Lip and Palate in Pediatric Patients and Their Association with Demographic Factors: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Cleft lip and/or palate mortality trends in the USA: a retrospective population-based study.BMJ paediatrics open · 2024Article
- A Cross-Sectional Study of the Dental Arch Relationship and Palatal Morphology after Cleft Surgery in Italian Children with Unilateral Cleft and Lip Palate.Children (Basel, Switzerland) · 2023Article
- The Efficacy of Curcumin Patch as an Adjuvant Therapeutic Agent in Managing Acute Orofacial Pain on the Post-Cleft Lip and Cleft Palate Surgery Patients: A Pragmatic Trial.European journal of dentistry · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA recently published validated classification system divides all orofacial cleft (OFC) subphenotypes into groups based on underlying developmental mechanisms, that is, fusion and differentiation, and their timing, that is, early and late periods, in embryogenesis of the primary and secondary palates.
aimsThe aim of our study was to define gender differences in prevalence for all subphenotypes in newborns with OFC in the Netherlands.
methodsThis was a retrospective cross-sectional study on children with OFC born from 2006 to 2016. Clefts were classified in early (E-), late (L-), and early/late (EL-) embryonic periods, in primary (P-), secondary (S-), and primary/secondary (PS-) palates, and further divided into fusion (F-), differentiation (D-), and fusion/differentiation (FD-) defects, respectively.
resultsA total of 2089 OFC children were analyzed (1311 males and 778 females). Orofacial cleft subphenotypes in females occurred significantly more frequent in the L-period compared to males (66% vs 55%,
conclusionsOrofacial cleft in females mainly occur in the L-period are mostly S-palatal clefts, and are usually the result of an F-defect. Orofacial cleft in males more commonly occur in the EL-periods, are therefore more often combined PS-palatal clefts, and are more frequent D- and FD-defects.
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