ArticleThe British journal of dermatology2021
Doppler ultrasound-based noninvasive biomarkers in hidradenitis suppurativa: evaluation of analytical and clinical validity.
Article in The British journal of dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Ultrasound-Guided Triamcinolone Injections for Hidradenitis Suppurativa Lesions: A Systematic Review and Meta-Analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Pooled it
- Identification of Biomarkers and Critical Evaluation of Biomarker Validation in Hidradenitis Suppurativa: A Systematic Review.JAMA dermatology · 2022Pooled it
- Role of Ultrasonography in the Diagnosis and Treatment of Hidradenitis Suppurativa: A Narrative Review.Indian dermatology online journal · 2026Article
- High-Frequency Ultrasound in Hidradenitis Suppurativa: From Lesion Detection to Iconographic Lesion-Level Management.American journal of clinical dermatology · 2026Review
- Ultrasonography of pediatric cutaneous and subcutaneous masses.Pediatric radiology · 2026Review
- Integrated Doppler and Elastography Assessment of Hidradenitis Suppurativa and Dactylitis.Diagnostics (Basel, Switzerland) · 2026Article
- Ultrasound monitoring of hidradenitis suppurativa fistulas in treatment with adalimumab.Dermatology reports · 2025Article
- Correlation Between Ultra-High Frequency Ultrasound (UHFUS) and Histological Features of Typical Lesions in Hidradenitis Suppurativa.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Hidradenitis suppurativa, from basic science to surgery and a new era of tailored targeted therapy: An expert opinion paper.Archives of dermatological research · 2025Review
- Advanced Doppler Ultrasound Insights: A Multicenter Prospective Study on Healthy Skin.Diagnostics (Basel, Switzerland) · 2025Article
- Ultrasound imaging of the axilla.Insights into imaging · 2023Review
- New Insight into the Molecular Pathomechanism and Immunomodulatory Treatments of Hidradenitis Suppurativa.International journal of molecular sciences · 2023Review
- How Adalimumab Impacts Antibiotic Prescriptions in Patients Affected by Hidradenitis Suppurativa: A 1-Year Prospective Study and Retrospective Analysis.Journal of clinical medicine · 2023Article
- The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris.Journal of the American Academy of Dermatology · 2022Article
- Assessing the responsiveness of sonographic biomarkers to Brodalumab therapy in Hidradenitis Suppurativa.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa.The Journal of allergy and clinical immunology · 2021Article
- Doppler ultrasound protocol for patients with hidradenitis suppurativa.Anais brasileiros de dermatologiaReview
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4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is a need for valid and reliable biomarkers in hidradenitis suppurativa (HS) for diagnosis and disease activity monitoring. Imaging-based biomarkers have the potential to fulfil this unmet need but no evaluation of analytical or clinical validity has yet been undertaken.
objectivesTo evaluate the analytical and clinical validity of sonographic epidermal thickness, Doppler ultrasound and dermal tunnel diameter in patients with HS.
methodsTwenty-two participants with HS were recruited and underwent a total of 65 matched ultrasound and skin biopsies of lesional, perilesional and unaffected tissue. Ultrasound measurements were performed in triplicate with mean values used. Skin biopsies underwent immunohistochemistry as per previously published methods. Analytical validity was assessed in individual ultrasound-biopsy pairs (n = 65) by comparisons of sonographic variables with histological correlates. Clinical validity was assessed in individual patients (n = 22) by comparing measures of overall disease activity with sonographic outcomes.
resultsEpidermal thickness, dermal tunnel diameter and power Doppler intensity were assessed. Sonographic epidermal thickness and dermal tunnel diameter have high analytical validity with corresponding histological measurements. Power Doppler intensity demonstrated high correlation with dermal CD3
conclusionsSonographic epidermal thickness and dermal tunnel diameter have acceptable levels of analytical validity in the assessment of HS lesions. Power Doppler intensity demonstrates acceptable clinical and analytical validity, suggesting it is a valid imaging-based biomarker in HS.
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