Evidence map›Paper›PMID 32602054›Full record

ArticleJournal of clinical immunology2020

Treosulfan-Based Conditioning Regimen in Haematopoietic Stem Cell Transplantation with TCRαβ/CD19 Depletion in Nijmegen Breakage Syndrome.

Alexandra Laberko, Elvira Sultanova, Elena Gutovskaya, Svetlana Radygina, Elena Deripapa, Aishat Kantulaeva, Pavel Trakhtman, Varvara Brilliantova, Julia Starichkova, Anna Shcherbina and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Treosulfan-based conditioning for inborn errors of immunity.Therapeutic advances in hematology · 2021
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Alexandra LaberkoDepartment of Immunology, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, 1, Samory Mashela str, Moscow, Russia, 117997. alexandra.laberko@gmail.com.ORCID 0000-0002-2354-2588
Elvira SultanovaDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0003-0319-3699
Elena GutovskayaDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-3800-8927
Svetlana RadyginaDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-7696-1153
Elena DeripapaDepartment of Immunology, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, 1, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-9083-4783
Aishat KantulaevaDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0001-5962-1264
Pavel TrakhtmanLaboratory of Transplant Processing and Cell Preparations, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-0231-1617
Varvara BrilliantovaLaboratory of Molecular Biology, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0003-0079-7761
Julia StarichkovaDepartment of Bioinformatics and Medical Statistics, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0003-1804-9761
Anna ShcherbinaDepartment of Immunology, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, 1, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-3113-4939
Michael MaschanDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0003-1735-0093
Alexei MaschanDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0002-0016-6698
Dmitry BalashovDepartment of Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela str, Moscow, Russia, 117997.ORCID 0000-0003-2689-0569
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to malignancies. HSCT appears to cure immunodeficiency, but remains challenging due to limited experience in long-term risks of transplant-associated toxicity and malignancies. Twenty NBS patients received 22 allogeneic HSCTs with TCRαβ/CD19+ graft depletion with fludarabine 150 mg/m

Indexed as

Lymphocyte DepletionAntigens, CD19BusulfanFemaleGraft RejectionGraft SurvivalGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunosuppressive AgentsMaleMyeloablative AgonistsNijmegen Breakage SyndromePostoperative CarePrognosisReceptors, Antigen, T-Cell, alpha-betaAntigens, CD19BusulfanImmunosuppressive AgentsMyeloablative AgonistsReceptors, Antigen, T-Cell, alpha-betatreosulfanDNA repair disorderHaematopoietic stem cell transplantationNijmegen breakage syndromeTCRαβ/CD19 depletionTreosulfan

Identifiers

PMID32602054
OpenAlexW3040280278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.