Evidence map›Paper›PMID 32601969›Full record

ArticleBreast cancer research and treatment2020

Magnetic resonance imaging and bioimpedance evaluation of lymphatic abnormalities in patients with breast cancer treatment-related lymphedema.

Paula M C Donahue, Rachelle Crescenzi, Chelsea Lee, Maria Garza, Niral J Patel, Kalen J Petersen, Manus J Donahue

Open access · greenAbstract read
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paula M C DonahuePhysical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA.
Rachelle CrescenziDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Chelsea LeeDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Maria GarzaDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Niral J PatelDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Kalen J PetersenDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Manus J DonahueDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. mj.donahue@vumc.org.ORCID http://orcid.org/0000-0002-4123-9275
Vanderbilt University Medical Center · US

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Quantification of Glymphatic Dysfunction in Patients with Alzheimer's Disease and Related DementiasR01NR015079 · NINR · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DONAHUE, MANUS J · 2014 to 2022
$3.9M
NIBIB NIH HHS T32 EB001628NINR NIH HHS 1R01NR015079NINR NIH HHS R01 NR015079
6 · The paper itself

Abstract

purposeBreast cancer treatment-related lymphedema (BCRL) evaluation is frequently performed using portable measures of limb volume and bioimpedance asymmetry. Here quantitative magnetic resonance imaging (MRI) is applied to evaluate deep and superficial tissue impairment, in both surgical and contralateral quadrants, to test the hypothesis that BCRL impairment is frequently bilateral and extends beyond regions commonly evaluated with portable external devices.

methods3-T MRI was applied to investigate BCRL topographical impairment. Female BCRL (n = 33; age = 54.1 ± 11.2 years; stage = 1.5 ± 0.8) and healthy (n = 33; age = 49.4 ± 11.0 years) participants underwent quantitative upper limb MRI relaxometry (T

resultsBioimpedance asymmetry was significantly correlated with MRI-measured water relaxation (T

conclusionsRegional MRI measures substantiate a growing literature speculating that superficial and deep tissue, in surgical and contralateral quadrants, is affected in BCRL. The implications of these findings in the context of titrating treatment regimens and understanding malignancy recurrence are discussed.

Indexed as

Electric ImpedanceMagnetic Resonance ImagingAdultBreast Cancer LymphedemaFemaleHumansLymphatic AbnormalitiesMastectomyMiddle AgedMuscle, SkeletalYoung AdultBioimpedance spectroscopyBreast cancerLymphaticLymphedemaMRIRadiology

Identifiers

PMID32601969
PMCPMC8086787
OpenAlexW3039137179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.