Evidence map›Paper›PMID 32601949›Full record

ArticleEuropean radiology2020

CT-based radiomics to predict the pathological grade of bladder cancer.

Gumuyang Zhang, Lili Xu, Lun Zhao, Li Mao, Xiuli Li, Zhengyu Jin, Hao Sun

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gumuyang Zhang *Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Wangfujing Street, Dongcheng District, Beijing, 100730, China.
Lili Xu *Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Wangfujing Street, Dongcheng District, Beijing, 100730, China.
Lun ZhaoDeepwise AI Lab, Deepwise Inc., Haidian Avenue No. 8, Sinosteel International Plaza, Beijing, 100080, China.
Li MaoDeepwise AI Lab, Deepwise Inc., Haidian Avenue No. 8, Sinosteel International Plaza, Beijing, 100080, China.
Xiuli LiDeepwise AI Lab, Deepwise Inc., Haidian Avenue No. 8, Sinosteel International Plaza, Beijing, 100080, China.
Zhengyu JinDepartment of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Wangfujing Street, Dongcheng District, Beijing, 100730, China. jinzy@pumch.cn.
Hao SunDepartment of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1, Wangfujing Street, Dongcheng District, Beijing, 100730, China. sunhao_robert@126.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNSinosteel (China) · CNPeking Union Medical College Hospital · CN

Funding

Clinical and Translational Research Project of Chinese Academy of Medical Sciences 2019XK320028National Natural Science Foundation of China 81901742National Natural Science Foundation of China 91859119National Public Welfare Basic Scientific Research Project of Chinese Academy of Medical Sciences 2018PT32003 and 2019PT320008Natural Science Foundation of Beijing Municipality 7192176
6 · The paper itself

Abstract

objectiveTo build a CT-based radiomics model to predict the pathological grade of bladder cancer (BCa) preliminarily.

methodsPatients with surgically resected and pathologically confirmed BCa and who received CT urography (CTU) in our institution from October 2014 to September 2017 were retrospectively enrolled and randomly divided into training and validation groups. After feature extraction, we calculated the linear dependent coefficient between features to eliminate the collinearity. F-test was then used to identify the best features related to pathological grade. The logistic regression method was used to build the prediction model, and diagnostic performance was analyzed by plotting receiver operating characteristic (ROC) curve and calculating area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

resultsOut of 145 included patients, 108 constituted the training group and 37 the validation group. The AUC value of the radiomics prediction model to diagnose the pathological grade of BCa was 0.950 (95% confidence interval [CI] 0.912-0.988) in the training group and 0.860 (95% CI 0.742-0.979) in the validation group, respectively. In the validation group, the diagnostic accuracy, sensitivity, specificity, PPV, and NPV were 83.8%, 88.5%, 72.7%, 88.5%, and 72.7%, respectively.

conclusionsCT-based radiomics model can differentiate high-grade from low-grade BCa with a fairly good diagnostic performance. KEY POINTS: •CT-based radiomics model can predict the pathological grade of bladder cancer. •This model has good diagnostic performance to differentiate high-grade and low-grade bladder cancer. •This preoperative and non-invasive prediction method might become an important addition to biopsy.

Indexed as

Tomography, X-Ray ComputedAgedArea Under CurveDiagnosis, Computer-AssistedFemaleHumansMaleMiddle AgedNeoplasm StagingPredictive Value of TestsRegression AnalysisReproducibility of ResultsRetrospective StudiesROC CurveUrinary Bladder NeoplasmsPattern recognitionRadiomicsRetrospective studiesTomography, X-ray computedUrinary bladder neoplasms

Identifiers

PMID32601949
OpenAlexW3038020784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.