ArticleEJNMMI research2020
Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm.
Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Comparing the diagnostic efficacy of [Frontiers in medicine · 2025Pooled it
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- The SPECT/CT radiomics-based classification of skeletal metastases and benign bone lesions.Scientific reports · 2026Article
- Inter-institutional variability in kidney dosimetry duringRadiological physics and technology · 2026Article
- Instrumentation Digital Twins in PET and SPECT Imaging: Current Status, Challenges, and Future Directions.Computational and structural biotechnology journal · 2026Review
- Development of a novel phantom for evaluating jawbone SPECT targeting medication-related osteonecrosis of the jaw.Oral radiology · 2025Article
- Optimization of Image Quality in Pelvis Lymphoscintigraphy SPECT/CT Using Discovery NM/CT 670.World journal of nuclear medicine · 2025Article
- Prospective study ofThoracic cancer · 2024Article
- Detectability of cold tumors by xSPECT bone technology compared with hot tumors: a supine phantom study.Physical and engineering sciences in medicine · 2024Article
- Comparison of the detectability of hot lesions on bone SPECT using six state-of-the-art SPECT/CT systems: a multicenter phantom study to optimize reconstruction parameters.Physical and engineering sciences in medicine · 2023Article
- Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Quantification of bone metabolic activity in the natural course of fractural lesions measured by quantitative SPECT/CT.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Quantify total activity by volume-of-interest expansion with clinical SPECT/CT systems, a phantom study.Journal of applied clinical medical physics · 2023Article
- Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom.EJNMMI physics · 2022Article
- Clinical significance of quantitative bone SPECT/CT in the evaluation of hand and wrist pain in patients with rheumatic disease.Scientific reports · 2022Article
- Evaluation of quantitative accuracy among different scatter corrections for quantitative bone SPECT/CT imaging.PloS one · 2022Article
- Satisfied quantitative value can be acquired by short-time bone SPECT/CT using a whole-body cadmium-zinc-telluride gamma camera.Scientific reports · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstruction using images derived from phantoms and patients.
methodsA custom-designed body phantom for bone SPECT was scanned using a Symbia Intevo (Siemens Healthineers), and reconstructed xSPECT images were evaluated. The phantom experiments proceeded twice with different activity concentrations and sphere sizes. A phantom with 28-mm spheres containing a
resultsMean activity concentrations with various TBR converged according to increasing numbers of iterations. The spatial resolution of xB was considerably superior to xQ and F3D, and it approached almost the actual size regardless of the iteration numbers during reconstruction. The CV and RC were better for xQ and xB than for F3D. The CNR peaked at 24 iterations for xQ and 48 iterations for F3D and xB, respectively. The RC between xQ and xB significantly differed at lower numbers of iterations but were almost equivalent at higher numbers of iterations. The reconstructed xQ and xB images of the clinical patients showed a significant difference in the SUV
conclusionsThe reconstructed xQ and xB images were more accurate than those reconstructed conventionally using F3D. The xB for bone SPECT imaging offered essentially unchanged spatial resolution even when the numbers of iterations did not converge. The xB reconstruction further enhanced SPECT image quality using CT data. Our findings provide important information for understanding the performance characteristics of the novel xQ and xB algorithms.
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