Evidence map›Paper›PMID 32601752›Full record

ArticleTechniques in coloproctology2020

Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation.

D C Meyer, S S Hill, D M Bebinger, J A McDade, J S Davids, K Alavi, J A Maykel

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Techniques in coloproctology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Diarrhea management: from pathophysiology to microbiota modulation.Therapeutic advances in gastroenterology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

D C MeyerDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA.
S S HillDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA.
D M BebingerDivision of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
J A McDadeDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA.
J S DavidsDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA.
K AlaviDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA.
J A MaykelDivision of Colon and Rectal Surgery, University of Massachusetts Medical School, University of Massachusetts Memorial Medical Center, 67 Belmont Street, Worcester, MA, 01605, USA. justin.maykel@umassmemorial.org.ORCID http://orcid.org/0000-0001-9995-1647
University of Massachusetts Chan Medical School · USUMass Memorial Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe exact pathophysiology of diverticulitis is not well understood and may be multifactorial. Recent studies highlight dysbiosis as a plausible mechanism. FMT is a safe strategy to restore commensal colon microbiota and has proven to be an effective treatment for gastrointestinal dysbiosis such as Clostridium difficile infection (CDI). There have been no studies reporting the treatment of diverticulitis with FMT. Our aim was to describe the novel application of fecal microbiota transplantation (FMT) for the treatment of recurrent diverticulitis. CASE: We report a case of a 63-year-old woman who had a 13-year history of multiply recurrent and multifocal diverticulitis previously treated with numerous short courses of intravenous and oral antibiotics for acute flares, two segmental colon resections, and suppressive antibiotic therapy for recurrent disease. Secondary to multiple courses of antibiotics , the patient developed CDI. She was treated with a single round of FMT and subsequently stopped all antibiotics at the time of FMT.

resultsIn 20 months of follow-up, the patient has had no further recurrence of diverticulitis or CDI.

conclusionsFMT could prove to be a novel therapy for refractory diverticulitis but requires further investigation.

Indexed as

Clostridioides difficileClostridium InfectionsDiverticulitisFecal Microbiota TransplantationFecesFemaleHumansMiddle AgedRecurrenceTreatment OutcomeAntibiotic therapyColonic bacteriaColonic diseasesDiverticular diseaseGut inflammation

Identifiers

PMID32601752
OpenAlexW3039359180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.