Evidence map›Paper›PMID 32601619›Full record

Article... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics2017

Predicting Heart Rejection Using Histopathological Whole-Slide Imaging and Deep Neural Network with Dropout.

Li Tong, Ryan Hoffman, Shriprasad R Deshpande, May D Wang

Abstract read
In one paragraph

Article in ... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Improving Classification of Breast Cancer by Utilizing the Image Pyramids of Whole-Slide Imaging and Multi-Scale Convolutional Neural Networks.Proceedings : Annual International Computer Software and Applications Conference. COMPSAC · 2019
    Article
  10. Improved Prediction on Heart Transplant Rejection Using Convolutional Autoencoder and Multiple Instance Learning on Whole-Slide Imaging.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2019
    Article
  11. Prediction of Heart Transplant Rejection Using Histopathological Whole-Slide Imaging.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li TongDept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.
Ryan HoffmanDept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.
Shriprasad R DeshpandeSchool of Medicine, Emory University, Atlanta, GA, 30307, USA.
May D WangDept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Contrast-Enhanced and Image-Guided Surgery of Lung CancerR01CA163256 · NCI · EMORY UNIVERSITY · PI JO, HANJOONG, SINGHAL, SUNIL · 2011 to 2015
$6.5M
NCATS NIH HHS UL1 TR000454NCI NIH HHS R01 CA163256
6 · The paper itself

Abstract

Cardiac allograft rejection is one major limitation for long-term survival for patients with heart transplants. The endomyocardial biopsy is one gold standard to screen heart rejection for patients that have heart transplantation. However, manual identification of heart rejection is expensive and time-consuming. With the development of imaging processing techniques and machine learning tools, automatic prediction of heart rejection using whole-slide images is one promising approach to improve the care of patients with heart transplants. In this paper, we first develop a histopathological whole-slide image processing pipeline to extract features automatically. Then, we construct deep neural networks with and without regularization and dropout to classify the patients into nonrejection and rejection respectively. Our results show that neural networks with regularization and dropout can significantly reduce overfitting and achieve more stable accuracies.

Identifiers

PMID32601619
PMCPMC7324296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.