ArticleCurrent opinion in systems biology2019
Selected before selection: A case for inherent antigen bias in the T cell receptor repertoire.
Article in Current opinion in systems biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The ageing immune system and its battle with viruses.The Journal of general virology · 2026Review
- Perinatal γδ T cells: between invariance and diversity.Frontiers in immunology · 2026Review
- Distinct T-cell receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus.eLife · 2024Article
- Article
- TCR meta-clonotypes for biomarker discovery witheLife · 2021Article
- TCRβ rearrangements without a D segment are common, abundant, and public.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood.EBioMedicine · 2021Article
- Rapid Assessment of T-Cell Receptor Specificity of the Immune Repertoire.Nature computational science · 2021Article
- TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features.bioRxiv : the preprint server for biology · 2021Article
- Landscape of T-cell repertoires with public COVID-19-associated T-cell receptors in pre-pandemic risk cohorts.Clinical & translational immunology · 2021Article
- Population variability in the generation and selection of T-cell repertoires.PLoS computational biology · 2020Article
- The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes.eLife · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
T cell receptor recombination is frequently described as a random or semi-random process that belies the now well-established principle that recombination is extremely biased towards the generation of particular receptor chains. Here we describe the experimental and theoretical work arising from new TCR repertoire sequencing approaches, including the recognition of high rates of public receptors across individuals, estimates of the size and distribution of receptors in the naive repertoire, and the roles of evolutionary, thymic, and peripheral selection in generating public, pathogen-specific responses. Molecular studies of recombination that have identified epigenetic, transcriptional, and topological contributions to variable segment usage are presented as examples of possible mechanisms shaped by natural selection to bias the TCR repertoire. Lastly, we suggest experimental approaches that might contribute to resolving some of the controversies in these areas.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.