SynthesisMolecular psychiatry2020
The IMAGEN study: a decade of imaging genetics in adolescents.
Synthesis in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Weighted prevalence of biochemically verified substance use in healthy adolescents across the USA.Addiction (Abingdon, England) · 2026Observational
- Multi-organ imaging genetics: towards an integrated view of brain, body and brain diseases.Nature reviews. Neurology · 2026Review
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- The longitudinal structure of cognition in the ABCD study and associations with neural function and psychopathology: A Bayesian probabilistic principal components analysis.Developmental cognitive neuroscience · 2026Article
- Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood.bioRxiv : the preprint server for biology · 2026Article
- Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study.bioRxiv : the preprint server for biology · 2026Article
- Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts.bioRxiv : the preprint server for biology · 2026Article
- The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.Journal of the experimental analysis of behavior · 2026Review
- CLUES A Comprehensive Workflow for Integrating Geospatial Data in Biomedical Research.Nature communications · 2026Article
- Model-based analysis of stop-signal data reveals robust neural and clinical correlates of evidence accumulation but not inhibition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Unified Multi-Cohort Harmonisation and Normative Modelling of Neuroimaging Data via Hierarchical GAMLSS.bioRxiv : the preprint server for biology · 2026Article
- Characterising a stress-sensitive default mode network (DMN) deficit in major psychiatric disorders.Communications biology · 2026Article
- Adolescent multi-omics and Mendelian randomization reveal transdiagnostic molecular mechanisms in psychiatric disorders.Nature. Mental health · 2026Article
- Leveraging Machine Learning to Advance Alcohol Research: Current Applications, Challenges, and Opportunities.Alcohol research : current reviews · 2026Review
- Article
- Identifying impulsivity and substance use measures in neuroimaging datasets: A scoping review and searchable dataset repository for researchers.Current addiction reports · 2026Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
Abstract
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.