ArticleNature cell biology2020
Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis.
Article in Nature cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
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- Morphodynamical adaptation of the endolysosomal system to stress.The FEBS journal · 2025Review
- A DNA nanodevice for mapping sodium at single-organelle resolution.Nature biotechnology · 2024Article
- Cell dehydration enables massive production of engineered membrane vesicles with therapeutic functions.Journal of extracellular vesicles · 2024Article
- Biosensors; a novel concept in real-time detection of autophagy.Biosensors & bioelectronics · 2024Review
- A dynamic cascade DNA nanocomplex to synergistically disrupt the pyroptosis checkpoint and relieve tumor hypoxia for efficient pyroptosis cancer therapy.Chemical science · 2024Article
- Canonical and non-canonical integrin-based adhesions dynamically interconvert.Nature communications · 2024Article
- NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.Cancer communications (London, England) · 2024Article
- Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy.Oncogenesis · 2022Article
- Article
- Inositol triphosphate signaling triggers lysosome biogenesis via calcium release from endoplasmic reticulum stores.Contact (Thousand Oaks (Ventura County, Calif.)) · 2022Article
- Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles.Journal of nanobiotechnology · 2021Review
- Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.Journal of cell science · 2021Article
- Lysosome biogenesis: Regulation and functions.The Journal of cell biology · 2021Review
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- The Golgi as a "Proton Sink" in Cancer.Frontiers in cell and developmental biology · 2021Article
- Article
- Endocytosis in the adaptation to cellular stress.Cell stress · 2020Review
- Endomembranes: Unsung Heroes of Mechanobiology?Frontiers in bioengineering and biotechnology · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosomes serve as cellular degradation and signalling centres that coordinate metabolism in response to intracellular cues and extracellular signals. Lysosomal capacity is adapted to cellular needs by transcription factors, such as TFEB and TFE3, which activate the expression of lysosomal and autophagy genes. Nuclear translocation and activation of TFEB are induced by a variety of conditions such as starvation, lysosome stress and lysosomal storage disorders. How these various cues are integrated remains incompletely understood. Here, we describe a pathway initiated at the plasma membrane that controls lysosome biogenesis via the endocytic regulation of intracellular ion homeostasis. This pathway is based on the exo-endocytosis of NHE7, a Na
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.