Evidence map›Paper›PMID 32601364›Full record

ArticleActa pharmacologica Sinica2021

Identification of critical molecular pathways involved in exosome-mediated improvement of cardiac function in a mouse model of muscular dystrophy.

Xuan Su, Yan Shen, Yue Jin, Neal L Weintraub, Yao-Liang Tang

Open access · bronzeAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Extracellular Vesicles for Muscle Atrophy Treatment.Advances in experimental medicine and biology · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xuan SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Yan ShenVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Yue JinVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Neal L WeintraubVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Yao-Liang TangVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. yaotang@augusta.edu.
Augusta University · US

Funding

Hypoxia and cardiac stem cell homingR01HL086555 · NHLBI · UNIVERSITY OF CINCINNATI · PI TANG, YAO LIANG · 2008 to 2019
$3.5M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
NHLBI NIH HHS R01 HL086555NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL142097
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a progressive disease characterized by skeletal muscle atrophy, respiratory failure, and cardiomyopathy. Our previous studies have shown that transplantation with allogeneic myogenic progenitor-derived exosomes (MPC-Exo) can improve cardiac function in X-linked muscular dystrophy (Mdx) mice. In the present study we explored the molecular mechanisms underlying this beneficial effect. We quantified gene expression in the hearts of two strains of Mdx mice (D2.B10-Dmd

Indexed as

AnimalsCardiomyopathiesDown-RegulationExosomesGene Expression ProfilingGene OntologyMaleMiceMice, Inbred mdxMuscular Dystrophy, DuchenneMyocardiumProtein Interaction MapsRNA-SeqUp-RegulationBcl-2cardiomyopathyDuchenne muscular dystrophyexosomegene ontologyIL-6protein-protein interaction networkRNA-Seq

Identifiers

PMID32601364
PMCPMC8115234
OpenAlexW3038079416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.