Evidence map›Paper›PMID 32601342›Full record

ArticleThe Journal of antibiotics2020

Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus.

Rawan Alnufaie, Nickolas Alsup, Hansa Raj Kc, Matthew Newman, Jedidiah Whitt, Steven Andrew Chambers, David Gilmore, Mohammad A Alam

Open access · greenAbstract read
In one paragraph

Article in The Journal of antibiotics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  9. Review
  10. Article
  11. Synthesis of 4,4'-(4-Formyl-1Antibiotics (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rawan AlnufaieDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Nickolas AlsupDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Hansa Raj KcDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Matthew NewmanDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Jedidiah WhittDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Steven Andrew ChambersDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
David GilmoreDepartment of Biological Sciences, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.
Mohammad A AlamDepartment of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA. malam@astate.edu.ORCID http://orcid.org/0000-0003-0258-3732
Arkansas State University · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

We report the synthesis and antimicrobial studies of a new series of naphthyl-substituted pyrazole-derived hydrazones. Many of these novel compounds are potent growth inhibitors of several strains of drug-resistant bacteria. These potent compounds have inclined growth inhibitory properties for planktonic Staphylococcus aureus and Acinetobacter baumannii, and its drug-resistant variants with minimum inhibitory concentration (MIC) as low as 0.78 and 1.56 µg ml

Indexed as

Drug DesignAcinetobacter baumanniiBiofilmsDrug Resistance, BacterialHydrazonesMicrobial Sensitivity TestsNaphthalenesStaphylococcus aureusHydrazonesNaphthalenes

Identifiers

PMID32601342
PMCPMC7655718
OpenAlexW3038717497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.