Evidence map›Paper›PMID 32601333›Full record

ArticleScientific reports2020

Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin.

R C Popescu, D Savu, I Dorobantu, B S Vasile, H Hosser, A Boldeiu, M Temelie, M Straticiuc, D A Iancu, E Andronescu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. Biomimetic FeCurrent pharmaceutical biotechnology · 2026
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  14. Magnetic-Responsive Doxorubicin-Containing Materials Based on FeInternational journal of molecular sciences · 2022
    Article
  15. One-Step Preparation of Highly Stable Copper-Zinc Ferrite Nanoparticles in Water Suitable for MRI Thermometry.Chemistry of materials : a publication of the American Chemical Society · 2022
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

R C Popescu"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Life and Environmental Physics, Reactorului 30, 077125, Magurele, Romania.
D Savu"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Life and Environmental Physics, Reactorului 30, 077125, Magurele, Romania. dsavu@nipne.ro.
I Dorobantu"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Life and Environmental Physics, Reactorului 30, 077125, Magurele, Romania.
B S VasilePolitehnica University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu 1-7, 011061, Bucharest, Romania.
H HosserHeidelberg University, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Center for Biomedicine and Medical Technology, Department of Anatomy and Developmental Biology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
A BoldeiuNational Institute for Research and Development in Microtechnologies, Laboratory of Nanobiotechnology, Erou Iancu Nicolae 12A, 077190, Bucharest, Romania.
M Temelie"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Life and Environmental Physics, Reactorului 30, 077125, Magurele, Romania.
M Straticiuc"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Applied Nuclear Physics, Reactorului 30, 077125, Magurele, Romania.
D A Iancu"Horia Hulubei" National Institute for Research and Development in Physics and Nuclear Engineering, Department of Applied Nuclear Physics, Reactorului 30, 077125, Magurele, Romania.
E AndronescuPolitehnica University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, Polizu 1-7, 011061, Bucharest, Romania.
F WenzUniversity Medical Center Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.
F A GiordanoHeidelberg University, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Department of Radiation Oncology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
C HerskindHeidelberg University, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Department of Radiation Oncology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
M R VeldwijkHeidelberg University, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Department of Radiation Oncology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. Marlon.Veldwijk@medma.uni-heidelberg.de.
Heidelberg University · DEUniversitatea Națională de Știință și Tehnologie Politehnica București · ROHoria Hulubei National Institute for R and D in Physics and Nuclear Engineering · RONational Institute for Research and Development in Microtechnologies · ROUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to construct and characterize iron oxide nanoparticles (IONP

Indexed as

Drug Delivery SystemsAntibiotics, AntineoplasticBiological TransportCell SurvivalDoxorubicinEndocytosisHeLa CellsHumansMagnetite NanoparticlesAntibiotics, AntineoplasticDoxorubicinMagnetite Nanoparticles

Identifiers

PMID32601333
PMCPMC7324358
OpenAlexW3037154647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.