ReviewNature reviews. Genetics2020
Polygenic adaptation: a unifying framework to understand positive selection.
Review in Nature reviews. Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 201 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
201 citing papers in PubMed.
- Effect of population structure and stabilizing selection on quantitative genetic variation.Genetics · 2026Article
- A Selective Sweep Likely Linked to Xenobiotic Detoxification Identified Along Altitudinal Gradients in the Pine Processionary Moth.Genome biology and evolution · 2026Article
- Polygenic and monogenic adaptation drive evolutionary rescue at different magnitudes of environmental change.The Journal of heredity · 2026Article
- Dissecting Fluctuating Selection: A Unified Population and Quantitative Genetics Framework.Genome biology and evolution · 2026Article
- Haplotype structure: an overlooked key factor shaping the genomic selection response.Genetics · 2026Article
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Genomic Evidence for Natural Selection Underlying High-Altitude Adaptive Hemoglobin Levels Among Peruvian Andeans.Genome biology and evolution · 2026Article
- Beyond fixation: persistent genetic variation under intense selection.Molecular biology and evolution · 2026Article
- Divergent habitat selection across many loci maintains species boundaries during introgression.bioRxiv : the preprint server for biology · 2026Article
- Parallel adaptation to geothermally-warmed habitats due to common structural variation and functional developmental pathways.Nature communications · 2026Article
- Haplotype and diversity signatures of ultra-soft selective sweeps in HIV-1.bioRxiv : the preprint server for biology · 2026Article
- Article
- Large-Scale Genomics Reveals Three-Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Experimental Evolution Under Biased Sex Ratios: Phenotypic and Genomic Responses in the Bulb Mite, Rhizoglyphus robini.Genome biology and evolution · 2026Article
- Beyond Fixation: Persistent Genetic Variation Under Intense Selection.bioRxiv : the preprint server for biology · 2026Article
- Adaptive value of marginal populations: integrating selective signals, neutral processes and temporal scales.Heredity · 2026Article
- Leveraging Genetic Diversity for Abiotic Stress Tolerance.International journal of molecular sciences · 2026Article
- Genetic basis of temporal variation in phenology in a woody perennial plant.NPJ systems biology and applications · 2026Article
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
141 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics - heterogeneity among loci and non-parallelism between replicated populations - are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.