Evidence map›Paper›PMID 32601313›Full record

ArticleScientific reports2020

Analyzing microglial-associated Aβ in Alzheimer's disease transgenic mice with a novel mid-domain Aβ-antibody.

Kristi Henjum, Vibeke Årskog, Charlotte B Jendresen, Tormod Fladby, Reidun Torp, Lars N G Nilsson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kristi HenjumDepartment of Pharmacology, University of Oslo and Oslo University Hospital, Blindern, P.O. 1057, 0316, Oslo, Norway.
Vibeke ÅrskogDepartment of Pharmacology, University of Oslo and Oslo University Hospital, Blindern, P.O. 1057, 0316, Oslo, Norway.
Charlotte B JendresenDepartment of Pharmacology, University of Oslo and Oslo University Hospital, Blindern, P.O. 1057, 0316, Oslo, Norway.
Tormod FladbyDepartment of Neurology, Faculty Division, Akershus University Hospital, University of Oslo, P.B. 1000, 1478, Lørenskog, Norway.
Reidun TorpDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Lars N G NilssonDepartment of Pharmacology, University of Oslo and Oslo University Hospital, Blindern, P.O. 1057, 0316, Oslo, Norway. lars.nilsson@medisin.uio.no.
Oslo University Hospital · NOUniversity of Oslo · NOAkershus University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms of amyloid-β (Aβ)-degradation and clearance in Alzheimer's disease (AD) pathogenesis have been relatively little studied. Short Aβ-fragments form by enzymatic cleavage and alternate amyloid-beta precursor protein (APP)-processing. Here we characterized a novel polyclonal Aβ-antibody raised against an Aβ mid-domain and used it to investigate microglial Aβ-uptake in situ by microscopy at the light- and ultrastructural levels. The rabbit Aβ-mid-domain antibody (ab338), raised against the mid-domain amino acids 21-34 (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAntibodiesDisease Models, AnimalHumansImmunoglobulin DomainsMiceMice, TransgenicMicrogliaPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAntibodies

Identifiers

PMID32601313
PMCPMC7324359
OpenAlexW3038107595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.