Observational studyScientific reports2020
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.
Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review.Immunity, inflammation and disease · 2023Pooled it
- The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.Physiology (Bethesda, Md.) · 2027Review
- Dysregulated iron metabolism in remodeling of aging asthmatic human airways.American journal of physiology. Cell physiology · 2026Article
- Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Review
- Differences in Redox Biomarkers in Bronchoalveolar Lavage Fluid of Leisure Horses With and Without Severe Equine Asthma: Preliminary Results.Animals : an open access journal from MDPI · 2026Article
- Dysregulated iron metabolism associates with neutrophilic airway inflammation in COPD.Clinical science (London, England : 1979) · 2026Article
- Ferritinophagy: molecular mechanisms and its crosstalk with ferroptosis in chronic respiratory diseases.Cell biology and toxicology · 2026Review
- Recent understanding of immunometabolic remodeling in pulmonary macrophages: homeostasis, chronic respiratory diseases, and therapeutic targeting.Frontiers in pharmacology · 2026Review
- Extracellular iron and the lung microbiome in smoking and COPD.ERJ open research · 2025Article
- Airway Extracellular Copper Concentrations Increase with Age and Are Associated with Oxidative Stress Independent of Disease State: A Case-Control Study Including Patients with Asthma and COPD.Antioxidants (Basel, Switzerland) · 2025Article
- NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.Respiratory research · 2025Article
- Iron Deficiency and All-Cause Hospitalization Risk in a Clinical Cohort of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Association between iron homeostasis and prognosis in patients with chronic obstructive pulmonary disease: a retrospective analysis from MIMIC-IV database.Frontiers in medicine · 2025Article
- Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients.Frontiers in pharmacology · 2025Article
- Associations of Vitamin D With GPX4 and Iron Parameters in Chronic Obstructive Pulmonary Disease Patients: A Case-Control Study.Canadian respiratory journal · 2024Article
- Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2023Article
- Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD.Journal of inflammation (London, England) · 2022Review
- Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease.Respiratory research · 2022Article
- Non-heme iron overload impairs monocyte to macrophage differentiationFrontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 14 institutions in 2 countries.
William Z ZhangJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Clara OromendiaJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Sarah Ann KikkersJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
James J ButlerJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Sarah O'BeirneJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Kihwan KimJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Wanda K O'NealUniversity of North Carolina Marsico Lung Institute, Chapel Hill, North Carolina, USA.
Christine M FreemanPulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
Stephanie A ChristensonUniversity of California at San Francisco, San Francisco, California, USA.
Stephen P PetersWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
J Michael WellsDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, UK.
Claire DoerschukUniversity of North Carolina Marsico Lung Institute, Chapel Hill, North Carolina, USA.
Nirupama PutchaJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, California, USA.
Prescott G WoodruffUniversity of California at San Francisco, San Francisco, California, USA.
Christopher B CooperDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles Medical Center, Los Angeles, California, USA.
Russell P BowlerUniversity of Colorado School of Medicine, Aurora, Colorado, USA.
Alejandro P ComellasDivision of Pulmonary and Critical Care, University of Iowa, Iowa City, Iowa, USA.
Gerard J CrinerDepartment of Pulmonary & Critical Care Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Robert PaineSection of Pulmonary and Critical Care Medicine, Salt Lake City Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
Nadia N HanselJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Meilan K HanPulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
Ronald G CrystalDepartment of Genetic Medicine, Weill Cornell Medicine, New York, New York, USA.
Robert J KanerJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Karla V BallmanJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Jeffrey L CurtisPulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
Fernando J MartinezJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA.
Suzanne M CloonanJoan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, USA. szc2009@med.cornell.edu.
University of North Carolina at Chapel Hill · USWeill Cornell Medicine · USCornell University · USLung Institute · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USJohns Hopkins Medicine · USJohns Hopkins University · USNewYork–Presbyterian Hospital · USTrinity College Dublin · IEUniversity of Alabama at Birmingham · USUniversity of Colorado Denver · USUniversity of Iowa · USVA Ann Arbor Healthcare System · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MRespiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9MThe CAPTURE Study: Validating a unique COPD screening tool in primary careR01HL136682 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2017 to 2021
$10.7MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MMultidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2MParametric Response Mapping in COPDR01HL122438 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAN, MEILAN K, MARTINEZ, FERNANDO J · 2014 to 2017
$4.0MStudy of Co-trimoxazole and Proton Pump Inhibition Using Pragmatic Design in Idiopathic Pulmonary Fibrosis - CleanUP-IPFU01HL128964 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANSTROM, KEVIN J, MARTINEZ, FERNANDO J · 2015 to 2018
$1.6MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MIdentifying the Th2 endotype in COPD: clinical and pathologic implicationsK23HL123778 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTENSON, STEPHANIE A · 2015 to 2019
$847kMitochondrial Iron metabolism in Chronic Obstructive Pulmonary DiseaseR00HL125899 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CLOONAN, SUZANNE M · 2017 to 2019
$747kNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL123778NHLBI NIH HHS K24 HL137013NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R00 HL125899NHLBI NIH HHS R01 HL122438NHLBI NIH HHS R01 HL136682NHLBI NIH HHS T32 HL134629NHLBI NIH HHS U01 HL128964NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIEHS NIH HHS P30 ES005605
Abstract
Levels of iron and iron-related proteins including ferritin are higher in the lung tissue and lavage fluid of individuals with chronic obstructive pulmonary disease (COPD), when compared to healthy controls. Whether more iron in the extracellular milieu of the lung associates with distinct clinical phenotypes of COPD, including increased exacerbation susceptibility, is unknown. We measured iron and ferritin levels in the bronchoalveolar lavage fluid (BALF) of participants enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD (SPIROMICS) bronchoscopy sub-study (n = 195). BALF Iron parameters were compared to systemic markers of iron availability and tested for association with FEV
Indexed as
AdultAgedAged, 80 and overBiomarkersBronchoalveolar Lavage FluidDisease ProgressionFemaleFerritinsForced Expiratory VolumeHumansIronIron-Binding ProteinsLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveBiomarkersFerritinsIronIron-Binding Proteins
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.