ArticleScientific reports2020
Numerical evaluation of spray position for improved nasal drug delivery.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 95 citations in OpenAlex.
- Intranasal drug delivery to the brain for neurodegenerative diseases: Current efforts and challenges in delivery platforms and modeling.Advanced drug delivery reviews · 2026Review
- CFD-Enabled Deep Insert Nasal Delivery for Precision Sinus Targeting.Pharmaceutical research · 2026Article
- Article
- Regional Nasal Drug Deposition in Pediatric vs. Adult Models: In vitro Insights into User Technique and Breathing Patterns Sensitivity.Pharmaceutical research · 2026Article
- Microneedle patch-based transnasal delivery of naloxone.Drug delivery and translational research · 2026Article
- Intranasal biomaterials for treatment-resistant depression: device-formulation coupling and therapeutic exposure.Frontiers in bioengineering and biotechnology · 2026Article
- Decoding the mechanophysiology for inhaled onset of smallpox with model-based implications for mpox spread.Scientific reports · 2025Article
- Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases.Acta pharmaceutica Sinica. B · 2025Article
- Comparative analysis of drug deposition patterns among three commercial nasal spray brands: A computational and experimental study.Journal of molecular liquids · 2025Article
- Computational Modeling of Nasal Cavity Aerodynamics: Implications for Surgical Outcomes and Targeted Drug Administration.Ear, nose, & throat journal · 2025Article
- Mechanics-guided parametric modeling of intranasal spray devices and formulations for targeted drug delivery to the nasopharynx.Frontiers in drug delivery · 2025Article
- Article
- Perspectives on physics-based one-dimensional modeling of lung physiology.Frontiers in physiology · 2025Article
- Long-term olfactory loss post-COVID-19: Pathobiology and potential therapeutic strategies.World journal of otorhinolaryngology - head and neck surgery · 2024Review
- In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route.AAPS PharmSciTech · 2024Review
- Assessing Nasal Epithelial Dynamics: Impact of the Natural Nasal Cycle on Intranasal Spray Deposition.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Olfactory drug delivery with intranasal sprays after nasal midvault reconstruction.International journal of pharmaceutics · 2023Article
- Development of a multiphase perfusion model for biomimetic reduced-order dense tumors.Experimental and computational multiphase flow · 2023Article
- Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model.Pharmaceutics · 2023Article
- Computational optimization of delivery parameters to guide the development of targeted Nasal spray.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
Abstract
Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified a new usage strategy for nasal sprays available over-the-counter, that registers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to prevalent spray techniques. The protocol involves re-orienting the spray axis to harness inertial motion of particulates and has been developed using computational fluid dynamics simulations of respiratory airflow and droplet transport in medical imaging-based digital models. Simulated dose in representative models is validated through in vitro spray measurements in 3D-printed anatomic replicas using the gamma scintigraphy technique. This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose. While these findings can eventually translate into personalized spray usage instructions and hence merit a change in nasal standard-of-care, this study also demonstrates how relatively simple engineering analysis tools can revolutionize everyday healthcare. Finally, with respiratory mucosa as the initial coronavirus infection site, our findings are relevant to intra-nasal vaccines that are in-development, to mitigate the COVID-19 pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.