ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Reinforcement Learning during Adolescence in Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Reward-specific learning parameters change across normative adolescent development and are blunted in youth with high risk for depression.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.Biological psychiatry global open science · 2025Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.Molecular psychiatry · 2024Article
- Adolescent-to-adult gains in cognitive flexibility are adaptively supported by reward sensitivity, exploration, and neural variability.Current opinion in behavioral sciences · 2024Article
- Associations between nesting, stereotypy, and working memory in deer mice: response to levetiracetam.Pharmacological reports : PR · 2023Article
- Cocaine reward and reinstatement in adolescent versus adult rodents.Frontiers in behavioral neuroscience · 2023Review
- Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats.Psychopharmacology · 2022Article
- Pruning recurrent neural networks replicates adolescent changes in working memory and reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reinforcement learning detuned in addiction: integrative and translational approaches.Trends in neurosciences · 2022Review
- Persistent behavioral and neurobiological consequences of social isolation during adolescence.Seminars in cell & developmental biology · 2021Review
- Review
- Unlocking the reinforcement-learning circuits of the orbitofrontal cortex.Behavioral neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The most dynamic period of postnatal brain development occurs during adolescence, the period between childhood and adulthood. Neuroimaging studies have observed morphologic and functional changes during adolescence, and it is believed that these changes serve to improve the functions of circuits that underlie decision-making. Direct evidence in support of this hypothesis, however, has been limited because most preclinical decision-making paradigms are not readily translated to humans. Here, we developed a reversal-learning protocol for the rapid assessment of adaptive choice behavior in dynamic environments in rats as young as postnatal day 30. A computational framework was used to elucidate the reinforcement-learning mechanisms that change in adolescence and into adulthood. Using a cross-sectional and longitudinal design, we provide the first evidence that value-based choice behavior in a reversal-learning task improves during adolescence in male and female Long-Evans rats and demonstrate that the increase in reversal performance is due to alterations in value updating for positive outcomes. Furthermore, we report that reversal-learning trajectories in adolescence reliably predicted reversal performance in adulthood. This novel behavioral protocol provides a unique platform for conducting biological and systems-level analyses of the neurodevelopmental mechanisms of decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.