Evidence map›Paper›PMID 32601236›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K

Arash Moshkforoush, Baarbod Ashenagar, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Mark T Nelson, Nikolaos M Tsoukias

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Pericyte KNature cardiovascular research · 2026
    Article
  3. Review
  4. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  12. Neurophotonics · 2025
    Article
  13. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Arash MoshkforoushDepartment of Biomedical Engineering, Florida International University, Miami, FL 33199.ORCID 0000-0003-4572-8911
Baarbod AshenagarDepartment of Biomedical Engineering, Florida International University, Miami, FL 33199.
Osama F HarrazDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0000-0003-2061-1100
Fabrice DabertrandDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405.ORCID 0000-0003-2541-9185
Thomas A LongdenDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405.
Mark T NelsonDepartment of Pharmacology, College of Medicine, University of Vermont, Burlington, VT 05405.
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, FL 33199; tsoukias@fiu.edu.ORCID 0000-0002-5164-9577
University of Vermont · USFlorida International University · USNational Technical University of Athens · GR

Funding

Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Capillary control of cerebral blood flow, and its disruption in small vessel diseaseR01HL136636 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Fabrice Dabertrand · 2017 to 2026
$3.8M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Integrative modeling to link vascular phenotype to gene expressionR15HL121778 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2014 to 2014
$424k
American Heart Association-American Stroke Association 17POST33650030NHLBI NIH HHS R01 HL136636NHLBI NIH HHS R15 HL121778NHLBI NIH HHS R35 HL140027NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

Neuronal activity leads to an increase in local cerebral blood flow (CBF) to allow adequate supply of oxygen and nutrients to active neurons, a process termed neurovascular coupling (NVC). We have previously shown that capillary endothelial cell (cEC) inwardly rectifying K

Indexed as

Neurovascular CouplingAnimalsBrainCerebrovascular CirculationEndothelial CellsMaleMiceMice, Inbred C57BLModels, BiologicalNeuronsPotassiumPotassium Channels, Inwardly RectifyingSignal TransductionTRPV Cation ChannelsKir2.1 channelPotassiumPotassium Channels, Inwardly RectifyingTrpv4 protein, mouseTRPV Cation Channelscerebral blood flowcomputational modelingelectrical conductioninward-rectifying potassiumneurovascular unit

Identifiers

PMID32601236
PMCPMC7368319
OpenAlexW3037409646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.