ArticleProceedings of the National Academy of Sciences of the United States of America2020
JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
What it found
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance.Nature reviews. Gastroenterology & hepatology · 2023Guideline
- Liver dysfunction associated with severe acute pancreatitis: molecular mechanisms and clinical insights.Hepatobiliary surgery and nutrition · 2026Article
- Integrated single-cell and bulk RNA sequencing analysis identifies a pyroptosis related prognostic model for predicting prognosis and therapeutic response in intrahepatic cholangiocarcinoma.Discover oncology · 2026Article
- Attack of the kinases: JNK signaling in metabolism.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Review
- Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Pleiotropic immunoregulation by bile acids in pathophysiology.Frontiers in immunology · 2026Review
- Cholangiocarcinoma cells direct fatty acids to support membrane synthesis and modulate macrophage phenotype.Hepatology communications · 2025Article
- Hepatic Nuclear Receptors in Cholestasis-to-Cholangiocarcinoma Pathology.The American journal of pathology · 2025Review
- Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation.International journal of molecular medicine · 2025Article
- Targeting the gut-liver axis in cholangiocarcinoma: mechanisms, therapeutic advances, and future directions.Frontiers in oncology · 2025Review
- The Biological Clock of Liver Metabolism in Metabolic Dysfunction-Associated Steatohepatitis Progression to Hepatocellular Carcinoma.Biomedicines · 2024Review
- Natural Compounds for Preventing Age-Related Diseases and Cancers.International journal of molecular sciences · 2024Review
- JNKs protect from cholestatic liver disease progression by modulating Apelin signalling.JHEP reports : innovation in hepatology · 2023Article
- The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.Journal of experimental & clinical cancer research : CR · 2023Article
- Plasma Bile Acid Profiling and Modulation of Secreted Mucin 5AC in Cholangiocarcinoma.International journal of molecular sciences · 2023Article
- Article
- Review
- Type 2 Diabetes Mellitus and Liver Disease: Across the Gut-Liver Axis from Fibrosis to Cancer.Nutrients · 2023Review
- Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study.Cancer reports (Hoboken, N.J.) · 2023Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Elisa ManieriCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.ORCID 0000-0002-7525-019X
Cintia FolgueiraCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.ORCID 0000-0003-3803-9149
María Elena RodríguezCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
Luis Leiva-VegaCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
Laura Esteban-LafuenteCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.ORCID 0000-0002-8311-0920
Chaobo ChenDepartment of Immunology, Ophthalmology, and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.ORCID 0000-0001-5963-5295
Francisco Javier CuberoDepartment of Immunology, Ophthalmology, and ENT, Complutense University School of Medicine, 28040 Madrid, Spain.
Tamera BarrettProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
Julie Cavanagh-KyrosProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.ORCID 0000-0001-7003-516X
Davide SeruggiaDivision of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0001-5014-0499
Alejandro RosellCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.ORCID 0000-0001-8028-8144
Fátima Sanchez-CaboCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.ORCID 0000-0003-1881-1664
Manuel Jose GómezCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain.
Maria J MonteLaboratory of Experimental Hepatology and Drug Targeting, National Institute for Study of Liver and Gastrointestinal Diseases (CIBERehd), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1844-7428
Jose J G MarinLaboratory of Experimental Hepatology and Drug Targeting, National Institute for Study of Liver and Gastrointestinal Diseases (CIBERehd), University of Salamanca, 37007 Salamanca, Spain.ORCID 0000-0003-1186-6849
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605; roger.davis@umassmed.edu amora@cnic.es guadalupe.sabio@cnic.es.ORCID 0000-0002-0130-1652
Alfonso MoraCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain; roger.davis@umassmed.edu amora@cnic.es guadalupe.sabio@cnic.es.ORCID 0000-0002-6397-4836
Guadalupe SabioCentro Nacional de Investigaciones Cardiovasculares, Myocardial Pathophysiology Area, 28029 Madrid, Spain; roger.davis@umassmed.edu amora@cnic.es guadalupe.sabio@cnic.es.ORCID 0000-0002-2822-0625
Spanish National Centre for Cardiovascular Research · ESUniversity of Massachusetts Chan Medical School · USUniversidad Complutense de Madrid · ESUniversidad de Salamanca · ESBoston Children's Hospital · USConsejo Superior de Investigaciones Científicas · ES
Funding
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6MPromotion of fatty liver disease by the ASK1 pathwayR01DK121545 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2019 to 2021
$1.6MNIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK121545
Abstract
Metabolic stress causes activation of the cJun NH
Indexed as
AnimalsBile Acids and SaltsCholangiocarcinomaHomeostasisHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9PPAR alphaBile Acids and SaltsMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9PPAR alphaPpara protein, mousebile acidcholangiocarcinomaJNKPPARa
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.