Evidence map›Paper›PMID 32601219›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.

Xiaobo Chen, Jiayue Chen, Bing Yan, Wei Zhang, Luke W Guddat, Xiang Liu, Zihe Rao

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Evaluation of the role ofMicrobiology spectrum · 2025
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  14. Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaobo ChenState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China.ORCID 0000-0001-8122-7888
Jiayue ChenState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China.
Bing YanState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China.
Wei ZhangState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China.
Luke W GuddatSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD, Australia.ORCID 0000-0002-8204-8408
Xiang LiuState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China; liux@nankai.edu.cn.ORCID 0000-0001-5498-6942
Zihe RaoState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, 300071 Tianjin, China.ORCID 0000-0001-9866-2384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FadE, an acyl-CoA dehydrogenase, introduces unsaturation to carbon chains in lipid metabolism pathways. Here, we report that FadE5 from

Indexed as

Acyl-CoA DehydrogenaseAcyl Coenzyme AAnti-Bacterial AgentsBacterial ProteinsBinding SitesCatalytic DomainDrug Resistance, BacterialFatty AcidsModels, MolecularMutationMycobacteriumProtein ConformationStructure-Activity RelationshipSubstrate SpecificityAcyl-CoA DehydrogenaseAcyl Coenzyme AAnti-Bacterial AgentsBacterial ProteinsFatty Acidsacyl-CoA dehydrogenasefatty acidmycobacteriatuberculosis

Identifiers

PMID32601219
PMCPMC7368279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.