Evidence map›Paper›PMID 32601218›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells.

Lorenza Garribba, Victoria A Bjerregaard, Marisa M Gonçalves Dinis, Özgün Özer, Wei Wu, Despoina Sakellariou, Javier Pena-Diaz, Ian D Hickson, Ying Liu

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Mitotic kinase regulation of DNA replication forks.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
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  13. Mechanisms of theInternational journal of molecular sciences · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Homologous recombination within repetitive DNA.Current opinion in genetics & development · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lorenza GarribbaCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0003-1840-7354
Victoria A BjerregaardCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Marisa M Gonçalves DinisCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0002-4058-6443
Özgün ÖzerCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0002-6444-0692
Wei WuCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Despoina SakellariouCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0001-5894-7879
Javier Pena-DiazCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.ORCID 0000-0002-6316-6011
Ian D HicksonCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Ying LiuCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark; ying@sund.ku.dk.ORCID 0000-0003-3703-2498
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the

Indexed as

MitosisDNADNA RepairEndodeoxyribonucleasesFolic AcidFragile X SyndromeHumansRad51 RecombinaseRad52 DNA Repair and Recombination ProteinRecombinasesDNAEndodeoxyribonucleasesFolic AcidRad51 RecombinaseRad52 DNA Repair and Recombination ProteinRecombinasesSLX1 protein, humanSLX4 protein, humanbreak-induced DNA replication (BIR)chromosome fragile siteshomologous recombinationMiDASstructure-specific endonucleases

Identifiers

PMID32601218
PMCPMC7368274
OpenAlexW3039779782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.