ArticleProceedings of the National Academy of Sciences of the United States of America2020
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
44 citing papers in PubMed, 69 citations in OpenAlex.
- Targeting Macrophage STING O-GlcNAcylation via Small-Molecule Allosteric Modulation for Psoriasis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Glycosylation modification: a trigger for obesity and its complications?Molecular medicine (Cambridge, Mass.) · 2026Review
- Genetic manipulation of OGT enhances NK cell-mediated cytotoxicity in tumor immunity.Journal of advanced research · 2026Article
- Identification and quantification of intracellular N-acetylglucosamine modified glycoRNAs.Nature communications · 2026Article
- Glucosamine as a regulator of O-GlcNAc signaling: linking metabolism to disease pathogenesis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Modulation and Reprogramming of Adipose Tissue Macrophages in Obesity.Biomolecules · 2026Review
- O-GlcNAcylation in diabetic cardiac remodeling and a proposed endothelial-macrophage-fibroblast network.Frontiers in immunology · 2026Review
- O-GlcNAcylation: A Nutrient-Sensitive Metabolic Rheostat in Antiviral Immunity and Viral Pathogenesis.Cells · 2025Review
- Crosstalk between O-GlcNAcylation and phosphorylation in metabolism: regulation and mechanism.Cell death and differentiation · 2025Review
- FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation.Frontiers in immunology · 2025Article
- OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis.Journal of orthopaedic translation · 2025Article
- Investigating the Regulation of Ribosomal Protein S6 Kinase 1 by CoAlation.International journal of molecular sciences · 2024Article
- Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling.Cell communication and signaling : CCS · 2024Review
- O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology.Cell communication and signaling : CCS · 2024Review
- Unraveling the complex roles of macrophages in obese adipose tissue: an overview.Frontiers of medicine · 2024Review
- Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage.Cell communication and signaling : CCS · 2024Article
- The role of O-GlcNAcylation in bone metabolic diseases.Frontiers in physiology · 2024Review
- Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome.Molecular biomedicine · 2023Article
- Review
- The role of O-GlcNAcylation in innate immunity and inflammation.Journal of molecular cell biology · 2023Review
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Authors and funding
21 authors at 2 institutions in 1 country.
Yunfan YangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-5266-7208
Xiruo LiDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.
Harding H LuanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.
Bichen ZhangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-0150-1267
Kaisi ZhangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Jin Hyun NamDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425.ORCID 0000-0003-2165-5287
Zongyu LiDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.
Minnie FuProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Alexander MunkDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520.
Dongyan ZhangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-4036-3987
Simeng WangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Yuyang LiuProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
João Paulo AlbuquerqueProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Qunxiang OngProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Rui LiProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Qi WangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
Marie E RobertDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06520.
Rachel J PerryDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0003-0748-8064
Dongjun ChungDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425.ORCID 0000-0002-8072-5671
Gerald I ShulmanDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0003-1529-5668
Xiaoyong YangProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520; xiaoyong.yang@yale.edu.
Yale University · USMedical University of South Carolina · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MTranslational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2001 to 2020
$25.6MYale Mouse Metabolic Phenotyping CenterU24DK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2001 to 2015
$8.9MResource CoreP30AR072582 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JAMES C OATES · 2017 to 2026
$8.5MThe Genetic Basis of Opioid Dependence Vulnerablility in a Rodent ModelU01DA045300 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christine Cheng, Dongjun Chung · 2018 to 2026
$6.1MEffects of Hepatic Acetyl-CoA Carboxylase Inhibition on NAFLD and Hepatic Insulin ResistanceR01DK113984 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2017 to 2021
$3.7MO-GlcNAc Modification in Metabolic HomeostasisR01DK089098 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2010 to 2021
$3.0MStatistical Models for Genetic Studies, Using Network and Integrative AnalysisR01GM122078 · NIGMS · OHIO STATE UNIVERSITY · PI CHUNG, DONGJUN · 2016 to 2020
$1.9MO-GlcNAc Signaling in Central Control of Energy BalanceR01DK102648 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2016 to 2019
$1.8MGlucagon Regulation of Hepatic Mitochondrial Activity and Glucose Metabolism by InsP3R-1R01DK116774 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2018 to 2021
$1.7MAlgorithms for Literature-Guided Multi-Platform Identification of Cancer SubtypesR21CA209848 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHUNG, DONGJUN, KELEMEN, LINDA E · 2016 to 2017
$358kNCATS NIH HHS UL1 TR001863NCI NIH HHS K99 CA215315NCI NIH HHS R21 CA209848NIAMS NIH HHS P30 AR072582NIDA NIH HHS U01 DA045300NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK089098NIDDK NIH HHS R01 DK102648NIDDK NIH HHS R01 DK113984NIDDK NIH HHS R01 DK116774NIDDK NIH HHS U24 DK059635NIGMS NIH HHS R01 GM122078
Abstract
Enhanced inflammation is believed to contribute to overnutrition-induced metabolic disturbance. Nutrient flux has also been shown to be essential for immune cell activation. Here, we report an unexpected role of nutrient-sensing
Indexed as
AcetylglucosamineAdipose TissueAnimalsHumansMacrophage ActivationMacrophagesMiceMice, KnockoutN-AcetylglucosaminyltransferasesObesityPhosphorylationRibosomal Protein S6 Kinases, 90-kDaSignal TransductionAcetylglucosamineN-AcetylglucosaminyltransferasesO-GlcNAc transferaseRibosomal Protein S6 Kinases, 90-kDaRps6ka1 protein, mouseimmunometabolismknockout micemetabolic homeostasisRNA sequencing
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